BCSC_ECOLI
ID BCSC_ECOLI Reviewed; 1157 AA.
AC P37650; P76710; Q2M7J2;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 3.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Cellulose synthase operon protein C;
DE Flags: Precursor;
GN Name=bcsC; Synonyms=yhjL; OrderedLocusNames=b3530, JW5942;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT from 76.0 to 81.5 minutes.";
RL Nucleic Acids Res. 22:2576-2586(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP 594-595.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CHARACTERIZATION.
RC STRAIN=ECOR 10, ECOR 12, and TOB1;
RX PubMed=11260463; DOI=10.1046/j.1365-2958.2001.02337.x;
RA Zogaj X., Nimtz M., Rohde M., Bokranz W., Roemling U.;
RT "The multicellular morphotypes of Salmonella typhimurium and Escherichia
RT coli produce cellulose as the second component of the extracellular
RT matrix.";
RL Mol. Microbiol. 39:1452-1463(2001).
CC -!- FUNCTION: Required for maximal bacterial cellulose synthesis.
CC {ECO:0000250}.
CC -!- PATHWAY: Glycan metabolism; bacterial cellulose biosynthesis.
CC -!- MISCELLANEOUS: The genes bscA, bcsB, bcsZ and bcsC are constitutively
CC transcribed but cellulose synthesis occurs only when DgcC, a putative
CC transmembrane protein regulated by CsgD, is expressed. Cellulose
CC production is abolished in E.coli K12.
CC -!- SIMILARITY: Belongs to the AcsC/BcsC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB18507.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U00039; AAB18507.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAT48188.4; -; Genomic_DNA.
DR EMBL; AP009048; BAE77764.1; -; Genomic_DNA.
DR RefSeq; WP_001225124.1; NZ_SSZK01000039.1.
DR RefSeq; YP_026226.4; NC_000913.3.
DR PDB; 6TZK; X-ray; 1.85 A; A=710-1157.
DR PDBsum; 6TZK; -.
DR AlphaFoldDB; P37650; -.
DR SMR; P37650; -.
DR BioGRID; 4261634; 108.
DR STRING; 511145.b3530; -.
DR TCDB; 1.B.55.3.1; the poly acetyl glucosamine porin (pgaa) family.
DR PaxDb; P37650; -.
DR PRIDE; P37650; -.
DR EnsemblBacteria; AAT48188; AAT48188; b3530.
DR EnsemblBacteria; BAE77764; BAE77764; BAE77764.
DR GeneID; 948047; -.
DR KEGG; ecj:JW5942; -.
DR KEGG; eco:b3530; -.
DR PATRIC; fig|511145.12.peg.3641; -.
DR EchoBASE; EB2166; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG3118; Bacteria.
DR HOGENOM; CLU_001631_2_0_6; -.
DR InParanoid; P37650; -.
DR OMA; ANVEAMP; -.
DR PhylomeDB; P37650; -.
DR BioCyc; EcoCyc:EG12257-MON; -.
DR UniPathway; UPA00694; -.
DR PRO; PR:P37650; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 5.
DR InterPro; IPR008410; BCSC_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF05420; BCSC_C; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 4.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Cellulose biosynthesis; Reference proteome; Repeat; Signal;
KW TPR repeat.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1157
FT /note="Cellulose synthase operon protein C"
FT /id="PRO_0000106429"
FT REPEAT 62..95
FT /note="TPR 1"
FT REPEAT 112..145
FT /note="TPR 2"
FT REPEAT 269..302
FT /note="TPR 3"
FT REPEAT 303..336
FT /note="TPR 4"
FT REPEAT 351..384
FT /note="TPR 5"
FT REPEAT 385..418
FT /note="TPR 6"
FT REPEAT 461..494
FT /note="TPR 7"
FT REPEAT 603..636
FT /note="TPR 8"
FT REPEAT 710..744
FT /note="TPR 9"
FT CONFLICT 594..595
FT /note="AM -> V (in Ref. 1; AAB18507)"
FT /evidence="ECO:0000305"
FT HELIX 710..723
FT /evidence="ECO:0007829|PDB:6TZK"
FT HELIX 727..740
FT /evidence="ECO:0007829|PDB:6TZK"
FT HELIX 751..756
FT /evidence="ECO:0007829|PDB:6TZK"
FT HELIX 766..782
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 785..795
FT /evidence="ECO:0007829|PDB:6TZK"
FT TURN 799..801
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 804..817
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 820..835
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 847..849
FT /evidence="ECO:0007829|PDB:6TZK"
FT TURN 850..853
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 861..874
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 876..885
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 889..891
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 894..906
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 908..917
FT /evidence="ECO:0007829|PDB:6TZK"
FT HELIX 922..925
FT /evidence="ECO:0007829|PDB:6TZK"
FT TURN 932..935
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 938..952
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 959..973
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 975..993
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 995..1012
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 1016..1018
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 1028..1042
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 1044..1061
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 1064..1066
FT /evidence="ECO:0007829|PDB:6TZK"
FT HELIX 1070..1072
FT /evidence="ECO:0007829|PDB:6TZK"
FT HELIX 1075..1082
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 1089..1123
FT /evidence="ECO:0007829|PDB:6TZK"
FT STRAND 1127..1138
FT /evidence="ECO:0007829|PDB:6TZK"
FT HELIX 1154..1156
FT /evidence="ECO:0007829|PDB:6TZK"
SQ SEQUENCE 1157 AA; 127724 MW; E99ADBAF20C0DC20 CRC64;
MRKFTLNIFT LSLGLAVMPM VEAAPTAQQQ LLEQVRLGEA THREDLVQQS LYRLELIDPN
NPDVVAARFR SLLRQGDIDG AQKQLDRLSQ LAPSSNAYKS SRTTMLLSTP DGRQALQQAR
LQATTGHAEE AVASYNKLFN GAPPEGDIAV EYWSTVAKIP ARRGEAINQL KRINADAPGN
TGLQNNLALL LFSSDRRDEG FAVLEQMAKS NAGREGASKI WYGQIKDMPV SDASVSALKK
YLSIFSDGDS VAAAQSQLAE QQKQLADPAF RARAQGLAAV DSGMAGKAIP ELQQAVRANP
KDSEALGALG QAYSQKGDRA NAVANLEKAL ALDPHSSNND KWNSLLKVNR YWLAIQQGDA
ALKANNPDRA ERLFQQARNV DNTDSYAVLG LGDVAMARKD YPAAERYYQQ TLRMDSGNTN
AVRGLANIYR QQSPEKAEAF IASLSASQRR SIDDIERSLQ NDRLAQQAEA LENQGKWAQA
AALQRQRLAL DPGSVWITYR LSQDLWQAGQ RSQADTLMRN LAQQKSNDPE QVYAYGLYLS
GHDQDRAALA HINSLPRAQW NSNIQELVNR LQSDQVLETA NRLRESGKEA EAEAMLRQQP
PSTRIDLTLA DWAQQRRDYT AARAAYQNVL TREPANADAI LGLTEVDIAA GDKAAARSQL
AKLPATDNAS LNTQRRVALA QAQLGDTAAA QRTFNKLIPQ AKSQPPSMES AMVLRDGAKF
EAQAGDPTQA LETYKDAMVA SGVTTTRPQD NDTFTRLTRN DEKDDWLKRG VRSDAADLYR
QQDLNVTLEH DYWGSSGTGG YSDLKAHTTM LQVDAPYSDG RMFFRSDFVN MNVGSFSTNA
DGKWDDNWGT CTLQDCSGNR SQSDSGASVA VGWRNDVWSW DIGTTPMGFN VVDVVGGISY
SDDIGPLGYT VNAHRRPISS SLLAFGGQKD SPSNTGKKWG GVRADGVGLS LSYDKGEANG
VWASLSGDQL TGKNVEDNWR VRWMTGYYYK VINQNNRRVT IGLNNMIWHY DKDLSGYSLG
QGGYYSPQEY LSFAIPVMWR ERTENWSWEL GASGSWSHSR TKTMPRYPLM NLIPTDWQEE
AARQSNDGGS SQGFGYTARA LLERRVTSNW FVGTAIDIQQ AKDYAPSHFL LYVRYSAAGW
QGDMDLPPQP LIPYADW
