RUTE_ECO27
ID RUTE_ECO27 Reviewed; 196 AA.
AC B7UNZ1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Probable malonic semialdehyde reductase RutE {ECO:0000255|HAMAP-Rule:MF_01204};
DE EC=1.1.1.298 {ECO:0000255|HAMAP-Rule:MF_01204};
GN Name=rutE {ECO:0000255|HAMAP-Rule:MF_01204}; OrderedLocusNames=E2348C_1059;
OS Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=574521;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2348/69 / EPEC;
RX PubMed=18952797; DOI=10.1128/jb.01238-08;
RA Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT "Complete genome sequence and comparative genome analysis of
RT enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL J. Bacteriol. 191:347-354(2009).
CC -!- FUNCTION: May reduce toxic product malonic semialdehyde to 3-
CC hydroxypropionic acid, which is excreted. {ECO:0000255|HAMAP-
CC Rule:MF_01204}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) +
CC NADPH; Xref=Rhea:RHEA:26438, ChEBI:CHEBI:15378, ChEBI:CHEBI:16510,
CC ChEBI:CHEBI:33190, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.298; Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC -!- INDUCTION: Up-regulated by the nitrogen regulatory protein C (NtrC also
CC called GlnG) and repressed by RutR. {ECO:0000255|HAMAP-Rule:MF_01204}.
CC -!- SIMILARITY: Belongs to the nitroreductase family. HadB/RutE subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01204}.
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DR EMBL; FM180568; CAS08607.1; -; Genomic_DNA.
DR RefSeq; WP_001001173.1; NC_011601.1.
DR AlphaFoldDB; B7UNZ1; -.
DR SMR; B7UNZ1; -.
DR EnsemblBacteria; CAS08607; CAS08607; E2348C_1059.
DR KEGG; ecg:E2348C_1059; -.
DR HOGENOM; CLU_084441_0_0_6; -.
DR OMA; LMVVNIG; -.
DR Proteomes; UP000008205; Chromosome.
DR GO; GO:0035527; F:3-hydroxypropionate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019740; P:nitrogen utilization; IEA:UniProtKB-UniRule.
DR GO; GO:0006212; P:uracil catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd02148; RutE-like; 1.
DR Gene3D; 3.40.109.10; -; 1.
DR HAMAP; MF_01204; Oxidoreductase_RutE_HadB; 1.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR InterPro; IPR023936; RutE-like.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF55469; SSF55469; 1.
PE 3: Inferred from homology;
KW Flavoprotein; FMN; NAD; NADP; Oxidoreductase.
FT CHAIN 1..196
FT /note="Probable malonic semialdehyde reductase RutE"
FT /id="PRO_1000164650"
SQ SEQUENCE 196 AA; 21577 MW; D75F0FDB8B362869 CRC64;
MNEAVSPGAL STLFTDARTH NGWRETPVSD ETLREIYALM KWGPTSANCS PARIVFIRTA
EGKERLRPAL SSGNLQKTLT APVTAIVAWD SEFYERLPQL FPHGDARSWF TSSPQLAEET
AFRNSSMQAA YLIVACRALG LDTGPMSGFD RQYVDDAFFA GSTLKSNLLI NIGYGDSSKL
FARLPRLSFE EACGLL