RUTE_ECO45
ID RUTE_ECO45 Reviewed; 196 AA.
AC B7MIF5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Probable malonic semialdehyde reductase RutE {ECO:0000255|HAMAP-Rule:MF_01204};
DE EC=1.1.1.298 {ECO:0000255|HAMAP-Rule:MF_01204};
GN Name=rutE {ECO:0000255|HAMAP-Rule:MF_01204}; OrderedLocusNames=ECS88_1024;
OS Escherichia coli O45:K1 (strain S88 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585035;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S88 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: May reduce toxic product malonic semialdehyde to 3-
CC hydroxypropionic acid, which is excreted. {ECO:0000255|HAMAP-
CC Rule:MF_01204}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) +
CC NADPH; Xref=Rhea:RHEA:26438, ChEBI:CHEBI:15378, ChEBI:CHEBI:16510,
CC ChEBI:CHEBI:33190, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.298; Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC -!- INDUCTION: Up-regulated by the nitrogen regulatory protein C (NtrC also
CC called GlnG) and repressed by RutR. {ECO:0000255|HAMAP-Rule:MF_01204}.
CC -!- SIMILARITY: Belongs to the nitroreductase family. HadB/RutE subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01204}.
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DR EMBL; CU928161; CAR02355.1; -; Genomic_DNA.
DR RefSeq; WP_001001168.1; NC_011742.1.
DR AlphaFoldDB; B7MIF5; -.
DR SMR; B7MIF5; -.
DR EnsemblBacteria; CAR02355; CAR02355; ECS88_1024.
DR KEGG; ecz:ECS88_1024; -.
DR HOGENOM; CLU_084441_0_0_6; -.
DR OMA; THNGWLD; -.
DR Proteomes; UP000000747; Chromosome.
DR GO; GO:0035527; F:3-hydroxypropionate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019740; P:nitrogen utilization; IEA:UniProtKB-UniRule.
DR GO; GO:0006212; P:uracil catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd02148; RutE-like; 1.
DR Gene3D; 3.40.109.10; -; 1.
DR HAMAP; MF_01204; Oxidoreductase_RutE_HadB; 1.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR InterPro; IPR023936; RutE-like.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF55469; SSF55469; 1.
PE 3: Inferred from homology;
KW Flavoprotein; FMN; NAD; NADP; Oxidoreductase.
FT CHAIN 1..196
FT /note="Probable malonic semialdehyde reductase RutE"
FT /id="PRO_1000138689"
SQ SEQUENCE 196 AA; 21625 MW; D74414DB8B363879 CRC64;
MNEAVSPGAL STLFTDARTH NGWRETPVSD ETLREIYALM KWGPTSANCS PARIVFIRTA
EGKERLRPAL SSGNLQKTLT APVTAIVAWD SEFYERLPQL FPHGDARSWF TSSPQLAEET
AFRNSSMQAA YLIFACRALG LDTGPMSGFD RQYVDDAFFA GSTLKSNLLI NIGYGDSSKL
FARLPRLSFE EACGLL