ID   BCSE_SALTY              Reviewed;         523 AA.
AC   Q8ZLB5; Q7AY58;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Cyclic di-GMP binding protein BcsE {ECO:0000303|PubMed:24942809};
DE   AltName: Full=Cellulose biosynthesis protein BcsE;
GN   Name=bcsE {ECO:0000303|PubMed:11929533}; OrderedLocusNames=STM3622;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE, AND GENE
RP   NAME.
RC   STRAIN=LT2;
RX   PubMed=11929533; DOI=10.1046/j.1365-2958.2002.02802.x;
RA   Solano C., Garcia B., Valle J., Berasain C., Ghigo J.-M., Gamazo C.,
RA   Lasa I.;
RT   "Genetic analysis of Salmonella enteritidis biofilm formation: critical
RT   role of cellulose.";
RL   Mol. Microbiol. 43:793-808(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   FUNCTION, AND C-DI-GMP-BINDING.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=24942809; DOI=10.1111/mmi.12672;
RA   Fang X., Ahmad I., Blanka A., Schottkowski M., Cimdins A., Galperin M.Y.,
RA   Roemling U., Gomelsky M.;
RT   "GIL, a new c-di-GMP-binding protein domain involved in regulation of
RT   cellulose synthesis in enterobacteria.";
RL   Mol. Microbiol. 93:439-452(2014).
CC   -!- FUNCTION: Required for cellulose biosynthesis (PubMed:11929533). May
CC       have protease activity (PubMed:11929533), but BcsA is not targeted
CC       (PubMed:24942809). Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
CC       (PubMed:24942809). {ECO:0000269|PubMed:11929533,
CC       ECO:0000269|PubMed:24942809}.
CC   -!- DISRUPTION PHENOTYPE: Mutants lack the ability to produce a biofilm.
CC       {ECO:0000269|PubMed:11929533}.
CC   -!- SIMILARITY: Belongs to the BcsE family. {ECO:0000305}.
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DR   EMBL; AJ315148; CAC86200.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22482.1; -; Genomic_DNA.
DR   RefSeq; NP_462523.1; NC_003197.2.
DR   RefSeq; WP_001205760.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZLB5; -.
DR   SMR; Q8ZLB5; -.
DR   STRING; 99287.STM3622; -.
DR   PaxDb; Q8ZLB5; -.
DR   EnsemblBacteria; AAL22482; AAL22482; STM3622.
DR   GeneID; 1255145; -.
DR   KEGG; stm:STM3622; -.
DR   PATRIC; fig|99287.12.peg.3829; -.
DR   HOGENOM; CLU_039389_2_0_6; -.
DR   BioCyc; SENT99287:STM3622-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0035438; F:cyclic-di-GMP binding; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR017745; BcsE.
DR   Pfam; PF10995; CBP_GIL; 1.
DR   TIGRFAMs; TIGR03369; cellulose_bcsE; 1.
PE   1: Evidence at protein level;
KW   Cellulose biosynthesis; Hydrolase; Nucleotide-binding; Protease;
KW   Reference proteome.
FT   CHAIN           1..523
FT                   /note="Cyclic di-GMP binding protein BcsE"
FT                   /id="PRO_0000417573"
SQ   SEQUENCE   523 AA;  59263 MW;  541A3D4DDD4B8202 CRC64;
     MRDTVDPVFS LGISSLWDEL RHMPTGGVWW VNADRQQDAI SLVNQTIASQ TENANVAVIG
     MEGDPGKVIK LDESHGPEKI RLFTMPASEK GLYSLPHDLL CSVNPTHYFF ILICANNTWR
     NITSESLHKW LEKMNKWTRF HHCSLLVINP CNNSDKQSSL LMGEYRSLFG LASLRFQGDQ
     HLFDIAFWCN EKGVSARQQL LLCQQDERWT LSHQEETAIQ PRSDEKRILS HVAVLEGAPP
     LSEHWTLFDN NEALFNDART AQAATIIFSL TQNNQIEPLA RRIHTLRRQR GSALKIVVRE
     NIASLRATDE RLLLGCGANM IIPWNAPLSR CLTLIESVQG QQFSRYVPED ITTLLSMTQP
     LKLRGFQPWD TFCDAIHTMM SNTLLPADGK GVLVALRPVP GIRVEQALTL CRPNRTGDIM
     TIGGNRLVLF LSFCRVNDLD TALNHIFPLP TGDIFSNRMV WFEDKQISAE LVQMRLLSPE
     LWGTPLPLAK RADPVINAEH DGRIWRRIPE PLRLLDDTAE RAS