ID   RUTE_KLEP7              Reviewed;         196 AA.
AC   A6T798;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Probable malonic semialdehyde reductase RutE {ECO:0000255|HAMAP-Rule:MF_01204};
DE            EC=1.1.1.298 {ECO:0000255|HAMAP-Rule:MF_01204};
GN   Name=rutE {ECO:0000255|HAMAP-Rule:MF_01204};
GN   OrderedLocusNames=KPN78578_10080; ORFNames=KPN_01034;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May reduce toxic product malonic semialdehyde to 3-
CC       hydroxypropionic acid, which is excreted. {ECO:0000255|HAMAP-
CC       Rule:MF_01204}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) +
CC         NADPH; Xref=Rhea:RHEA:26438, ChEBI:CHEBI:15378, ChEBI:CHEBI:16510,
CC         ChEBI:CHEBI:33190, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.298; Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC   -!- SIMILARITY: Belongs to the nitroreductase family. HadB/RutE subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01204}.
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DR   EMBL; CP000647; ABR76469.1; -; Genomic_DNA.
DR   RefSeq; WP_004141442.1; NC_009648.1.
DR   AlphaFoldDB; A6T798; -.
DR   SMR; A6T798; -.
DR   STRING; 272620.KPN_01034; -.
DR   DNASU; 5339076; -.
DR   EnsemblBacteria; ABR76469; ABR76469; KPN_01034.
DR   KEGG; kpn:KPN_01034; -.
DR   HOGENOM; CLU_084441_0_0_6; -.
DR   OMA; THNGWLD; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0035527; F:3-hydroxypropionate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019740; P:nitrogen utilization; IEA:UniProtKB-UniRule.
DR   GO; GO:0006212; P:uracil catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02148; RutE-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   HAMAP; MF_01204; Oxidoreductase_RutE_HadB; 1.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   InterPro; IPR023936; RutE-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NAD; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..196
FT                   /note="Probable malonic semialdehyde reductase RutE"
FT                   /id="PRO_1000066142"
SQ   SEQUENCE   196 AA;  21581 MW;  99E49B966EB3AB59 CRC64;
     MNDAINHTAC ETLFTQARTH NGWLDKPVSD AQLQAVWDLM KMGPTSANCS PARIVFVRSA
     EGKEKLRPTL SSGNLQKTMQ APVTAIVAWD SAFYDRLPTL FPHGDARSWF TSSPQLAEET
     AFRNSSLQAA YLIFACRARG LDTGPMSGFD REKVDAAFFA DNGWKSNLLV NIGYGDPGKL
     YGRLPRLSFD EACLLA