RUTE_SHIFL
ID RUTE_SHIFL Reviewed; 196 AA.
AC Q83RV4; Q7C251;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Probable malonic semialdehyde reductase RutE {ECO:0000255|HAMAP-Rule:MF_01204};
DE EC=1.1.1.298 {ECO:0000255|HAMAP-Rule:MF_01204};
GN Name=rutE {ECO:0000255|HAMAP-Rule:MF_01204};
GN OrderedLocusNames=SF1011, S1081;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: May reduce toxic product malonic semialdehyde to 3-
CC hydroxypropionic acid, which is excreted. {ECO:0000255|HAMAP-
CC Rule:MF_01204}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) +
CC NADPH; Xref=Rhea:RHEA:26438, ChEBI:CHEBI:15378, ChEBI:CHEBI:16510,
CC ChEBI:CHEBI:33190, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.298; Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01204};
CC -!- INDUCTION: Up-regulated by the nitrogen regulatory protein C (NtrC also
CC called GlnG) and repressed by RutR. {ECO:0000255|HAMAP-Rule:MF_01204}.
CC -!- SIMILARITY: Belongs to the nitroreductase family. HadB/RutE subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01204}.
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DR EMBL; AE005674; AAN42637.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16522.1; -; Genomic_DNA.
DR RefSeq; NP_706930.1; NC_004337.2.
DR RefSeq; WP_001001165.1; NZ_WPGW01000134.1.
DR AlphaFoldDB; Q83RV4; -.
DR SMR; Q83RV4; -.
DR STRING; 198214.SF1011; -.
DR EnsemblBacteria; AAN42637; AAN42637; SF1011.
DR EnsemblBacteria; AAP16522; AAP16522; S1081.
DR GeneID; 1023955; -.
DR GeneID; 58391248; -.
DR KEGG; sfl:SF1011; -.
DR KEGG; sfx:S1081; -.
DR PATRIC; fig|198214.7.peg.1175; -.
DR HOGENOM; CLU_084441_0_0_6; -.
DR OMA; LMVVNIG; -.
DR OrthoDB; 1847197at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0035527; F:3-hydroxypropionate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019740; P:nitrogen utilization; IEA:UniProtKB-UniRule.
DR GO; GO:0006212; P:uracil catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd02148; RutE-like; 1.
DR Gene3D; 3.40.109.10; -; 1.
DR HAMAP; MF_01204; Oxidoreductase_RutE_HadB; 1.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR InterPro; IPR023936; RutE-like.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF55469; SSF55469; 1.
PE 3: Inferred from homology;
KW Flavoprotein; FMN; NAD; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..196
FT /note="Probable malonic semialdehyde reductase RutE"
FT /id="PRO_1000066147"
SQ SEQUENCE 196 AA; 21508 MW; 0FEE1928B24EA540 CRC64;
MNEAVSPGAL STLFTDARTH NGWRETPVSD ETLQELYALM KWGPTSANCS PARIVFIRTA
EGKERLRPAL SSGNLQKTLT APVTAIVAWD SEFYERLPLL FPHGDARSWF TSSPQLAEET
AFRNSSMQAA YLIVACRALG LDTGPMSGFD RQHVDDAFFA GSTLKSNLLI NIGYGDSSKL
FARLPRLSFE EACGLL