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RUTR_ECO57
ID   RUTR_ECO57              Reviewed;         212 AA.
AC   Q8X4Z7; Q7AFN0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=HTH-type transcriptional regulator RutR;
DE   AltName: Full=Rut operon repressor;
GN   Name=rutR; OrderedLocusNames=Z1512, ECs1259;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Master transcription regulator which represses the
CC       degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for
CC       maintenance of metabolic balance between pyrimidines and purines. It
CC       also regulates the synthesis of pyrimidine nucleotides and arginine
CC       from glutamine (carAB) and the supply of glutamate (gadABWX) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; AE005174; AAG55629.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34682.1; -; Genomic_DNA.
DR   PIR; A85646; A85646.
DR   PIR; C90786; C90786.
DR   RefSeq; NP_309286.1; NC_002695.1.
DR   RefSeq; WP_001302258.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X4Z7; -.
DR   SMR; Q8X4Z7; -.
DR   STRING; 155864.EDL933_1434; -.
DR   EnsemblBacteria; AAG55629; AAG55629; Z1512.
DR   EnsemblBacteria; BAB34682; BAB34682; ECs_1259.
DR   GeneID; 912884; -.
DR   KEGG; ece:Z1512; -.
DR   KEGG; ecs:ECs_1259; -.
DR   PATRIC; fig|386585.9.peg.1362; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_1_0_6; -.
DR   OMA; DPHHLIF; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR019915; Tscrpt_reg_pyr_util_RutR.
DR   InterPro; IPR013573; Tscrpt_reg_YcdC_C.
DR   Pfam; PF08362; TetR_C_3; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03613; RutR; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..212
FT                   /note="HTH-type transcriptional regulator RutR"
FT                   /id="PRO_0000234093"
FT   DOMAIN          17..77
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        39..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   212 AA;  23704 MW;  5DA47B85C960FD6C CRC64;
     MTQGAVKTTG KRSRAVSAKK KAILSAALDT FSQFGFHGTR LEQIAELAGV SKTNLLYYFP
     SKEALYIAVL RQILDIWLAP LKAFREDFAP LAAIKEYIRL KLEVSRDYPQ ASRLFCMEML
     AGAPLLMDEL TGDLKSLIDE KSALIAGWVK SGKLAPIDPQ HLIFMIWAST QHYADFAPQV
     EAVTGATLRD EVFFNQTVEN VQRIIIEGIR PR
 
 
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