RUTR_ECO57
ID RUTR_ECO57 Reviewed; 212 AA.
AC Q8X4Z7; Q7AFN0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=HTH-type transcriptional regulator RutR;
DE AltName: Full=Rut operon repressor;
GN Name=rutR; OrderedLocusNames=Z1512, ECs1259;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Master transcription regulator which represses the
CC degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for
CC maintenance of metabolic balance between pyrimidines and purines. It
CC also regulates the synthesis of pyrimidine nucleotides and arginine
CC from glutamine (carAB) and the supply of glutamate (gadABWX) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR EMBL; AE005174; AAG55629.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34682.1; -; Genomic_DNA.
DR PIR; A85646; A85646.
DR PIR; C90786; C90786.
DR RefSeq; NP_309286.1; NC_002695.1.
DR RefSeq; WP_001302258.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8X4Z7; -.
DR SMR; Q8X4Z7; -.
DR STRING; 155864.EDL933_1434; -.
DR EnsemblBacteria; AAG55629; AAG55629; Z1512.
DR EnsemblBacteria; BAB34682; BAB34682; ECs_1259.
DR GeneID; 912884; -.
DR KEGG; ece:Z1512; -.
DR KEGG; ecs:ECs_1259; -.
DR PATRIC; fig|386585.9.peg.1362; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_1_0_6; -.
DR OMA; DPHHLIF; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR019915; Tscrpt_reg_pyr_util_RutR.
DR InterPro; IPR013573; Tscrpt_reg_YcdC_C.
DR Pfam; PF08362; TetR_C_3; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR TIGRFAMs; TIGR03613; RutR; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..212
FT /note="HTH-type transcriptional regulator RutR"
FT /id="PRO_0000234093"
FT DOMAIN 17..77
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 39..58
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 212 AA; 23704 MW; 5DA47B85C960FD6C CRC64;
MTQGAVKTTG KRSRAVSAKK KAILSAALDT FSQFGFHGTR LEQIAELAGV SKTNLLYYFP
SKEALYIAVL RQILDIWLAP LKAFREDFAP LAAIKEYIRL KLEVSRDYPQ ASRLFCMEML
AGAPLLMDEL TGDLKSLIDE KSALIAGWVK SGKLAPIDPQ HLIFMIWAST QHYADFAPQV
EAVTGATLRD EVFFNQTVEN VQRIIIEGIR PR