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RUTR_ECOL6
ID   RUTR_ECOL6              Reviewed;         212 AA.
AC   P0ACU3; P75899;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=HTH-type transcriptional regulator RutR;
DE   AltName: Full=Rut operon repressor;
GN   Name=rutR; OrderedLocusNames=c1150;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Master transcription regulator which represses the
CC       degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for
CC       maintenance of metabolic balance between pyrimidines and purines. It
CC       also regulates the synthesis of pyrimidine nucleotides and arginine
CC       from glutamine (carAB) and the supply of glutamate (gadABWX) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN79618.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN79618.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000191701.1; NC_004431.1.
DR   AlphaFoldDB; P0ACU3; -.
DR   SMR; P0ACU3; -.
DR   STRING; 199310.c1150; -.
DR   PRIDE; P0ACU3; -.
DR   EnsemblBacteria; AAN79618; AAN79618; c1150.
DR   GeneID; 60667996; -.
DR   GeneID; 66670709; -.
DR   KEGG; ecc:c1150; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_1_0_6; -.
DR   OMA; DPHHLIF; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR019915; Tscrpt_reg_pyr_util_RutR.
DR   InterPro; IPR013573; Tscrpt_reg_YcdC_C.
DR   Pfam; PF08362; TetR_C_3; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03613; RutR; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..212
FT                   /note="HTH-type transcriptional regulator RutR"
FT                   /id="PRO_0000070636"
FT   DOMAIN          17..77
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        39..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   212 AA;  23688 MW;  E2459B85DFAC277A CRC64;
     MTQGAVKTTG KRSRAVSAKK KAILSAALDT FSQFGFHGTR LEQIAELAGV SKTNLLYYFP
     SKEALYIAVL RQILDIWLAP LKAFREDFAP LAAIKEYIRL KLEVSRDYPQ ASRLFCMEML
     AGAPLLMDEL TGDLKALIDE KSALIAGWVK SGKLAPIDPQ HLIFMIWAST QHYADFAPQV
     EAVTGATLRD EVFFNQTVEN VQRIIIEGIR PR
 
 
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