ID   RUTR_SHIFL              Reviewed;         212 AA.
AC   P0ACU4; P75899;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=HTH-type transcriptional regulator RutR;
DE   AltName: Full=Rut operon repressor;
GN   Name=rutR; OrderedLocusNames=SF1016, S1086;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Master transcription regulator which represses the
CC       degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for
CC       maintenance of metabolic balance between pyrimidines and purines. It
CC       also regulates the synthesis of pyrimidine nucleotides and arginine
CC       from glutamine (carAB) and the supply of glutamate (gadABWX) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; AE005674; AAN42642.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP16527.1; -; Genomic_DNA.
DR   RefSeq; NP_706935.1; NC_004337.2.
DR   RefSeq; WP_000191701.1; NZ_WPGW01000134.1.
DR   AlphaFoldDB; P0ACU4; -.
DR   SMR; P0ACU4; -.
DR   STRING; 198214.SF1016; -.
DR   EnsemblBacteria; AAN42642; AAN42642; SF1016.
DR   EnsemblBacteria; AAP16527; AAP16527; S1086.
DR   GeneID; 1024012; -.
DR   GeneID; 60667996; -.
DR   GeneID; 66670709; -.
DR   KEGG; sfl:SF1016; -.
DR   KEGG; sfx:S1086; -.
DR   PATRIC; fig|198214.7.peg.1180; -.
DR   HOGENOM; CLU_069356_1_0_6; -.
DR   OMA; DPHHLIF; -.
DR   OrthoDB; 2089619at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR019915; Tscrpt_reg_pyr_util_RutR.
DR   InterPro; IPR013573; Tscrpt_reg_YcdC_C.
DR   Pfam; PF08362; TetR_C_3; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03613; RutR; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..212
FT                   /note="HTH-type transcriptional regulator RutR"
FT                   /id="PRO_0000070637"
FT   DOMAIN          17..77
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        39..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   212 AA;  23688 MW;  E2459B85DFAC277A CRC64;
     MTQGAVKTTG KRSRAVSAKK KAILSAALDT FSQFGFHGTR LEQIAELAGV SKTNLLYYFP
     SKEALYIAVL RQILDIWLAP LKAFREDFAP LAAIKEYIRL KLEVSRDYPQ ASRLFCMEML
     AGAPLLMDEL TGDLKALIDE KSALIAGWVK SGKLAPIDPQ HLIFMIWAST QHYADFAPQV
     EAVTGATLRD EVFFNQTVEN VQRIIIEGIR PR