ID   BCTX1_BABCE             Reviewed;          30 AA.
AC   P59891;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Babycurus-toxin 1;
DE            Short=BcTx1;
DE   Flags: Fragment;
OS   Babycurus centrurimorphus (East African scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Babycurus.
OX   NCBI_TaxID=244728;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=9248005; DOI=10.1016/s0041-0101(96)00221-8;
RA   Ben Khalifa R., Stankiewicz M., Pelhate M., Serrano-Hernandez S.E.,
RA   Possani L.D., Hinkel H., Mebs D.;
RT   "Action of babycurus-toxin 1 from the east African scorpion Babycurus
RT   centrurimorphus on the isolated cockroach giant axon.";
RL   Toxicon 35:1069-1080(1997).
CC   -!- FUNCTION: Binds to sodium channels (Nav) and inhibits both the
CC       activation and inactivation of the activated channels, thereby blocking
CC       neuronal transmission. {ECO:0000269|PubMed:9248005}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. {ECO:0000305}.
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DR   AlphaFoldDB; P59891; -.
DR   SMR; P59891; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR002061; Scorpion_toxinL/defensin.
DR   Pfam; PF00537; Toxin_3; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51863; LCN_CSAB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>30
FT                   /note="Babycurus-toxin 1"
FT                   /id="PRO_0000066727"
FT   DOMAIN          2..>30
FT                   /note="LCN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   NON_TER         30
SQ   SEQUENCE   30 AA;  3248 MW;  3C0695E503AB34B2 CRC64;
     LKDGYPTNSK GCKISGCLPG ENKFCLNECQ