BD1L2_HUMAN
ID BD1L2_HUMAN Reviewed; 172 AA.
AC Q8IYS8; B3KXU4; Q8WW13;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Biorientation of chromosomes in cell division protein 1-like 2 {ECO:0000305};
DE AltName: Full=Biorientation of chromosomes in cell division protein 1 pseudogene {ECO:0000305};
DE AltName: Full=Protein FAM44C {ECO:0000305};
GN Name=BOD1L2 {ECO:0000312|HGNC:HGNC:28505};
GN Synonyms=BOD1P {ECO:0000312|HGNC:HGNC:28505},
GN FAM44C {ECO:0000312|HGNC:HGNC:28505};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in proper chromosome biorientation through
CC the detection or correction of syntelic attachments in mitotic
CC spindles. {ECO:0000250|UniProtKB:Q96IK1}.
CC -!- INTERACTION:
CC Q8IYS8; O43186: CRX; NbExp=3; IntAct=EBI-12118438, EBI-748171;
CC Q8IYS8; Q969G2: LHX4; NbExp=3; IntAct=EBI-12118438, EBI-2865388;
CC Q8IYS8; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12118438, EBI-16439278;
CC Q8IYS8; P31321: PRKAR1B; NbExp=3; IntAct=EBI-12118438, EBI-2805516;
CC Q8IYS8; Q12933: TRAF2; NbExp=3; IntAct=EBI-12118438, EBI-355744;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q96IK1}. Chromosome,
CC centromere, kinetochore {ECO:0000250|UniProtKB:Q96IK1}.
CC -!- SIMILARITY: Belongs to the BOD1 family. {ECO:0000305}.
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DR EMBL; AK127964; BAG54606.1; -; mRNA.
DR EMBL; AC100775; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC021740; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59322.1; -.
DR RefSeq; NP_001244893.1; NM_001257964.1.
DR AlphaFoldDB; Q8IYS8; -.
DR SMR; Q8IYS8; -.
DR BioGRID; 129806; 62.
DR IntAct; Q8IYS8; 6.
DR STRING; 9606.ENSP00000467843; -.
DR iPTMnet; Q8IYS8; -.
DR PhosphoSitePlus; Q8IYS8; -.
DR BioMuta; BOD1L2; -.
DR DMDM; 125987827; -.
DR MassIVE; Q8IYS8; -.
DR MaxQB; Q8IYS8; -.
DR PaxDb; Q8IYS8; -.
DR PeptideAtlas; Q8IYS8; -.
DR PRIDE; Q8IYS8; -.
DR ProteomicsDB; 71231; -.
DR Antibodypedia; 65878; 7 antibodies from 5 providers.
DR DNASU; 284257; -.
DR Ensembl; ENST00000585477.2; ENSP00000467843.1; ENSG00000228075.5.
DR GeneID; 284257; -.
DR KEGG; hsa:284257; -.
DR MANE-Select; ENST00000585477.2; ENSP00000467843.1; NM_001257964.2; NP_001244893.1.
DR UCSC; uc002lgm.4; human.
DR CTD; 284257; -.
DR GeneCards; BOD1L2; -.
DR HGNC; HGNC:28505; BOD1L2.
DR HPA; ENSG00000228075; Tissue enriched (testis).
DR neXtProt; NX_Q8IYS8; -.
DR OpenTargets; ENSG00000228075; -.
DR PharmGKB; PA166048984; -.
DR VEuPathDB; HostDB:ENSG00000228075; -.
DR eggNOG; ENOG502S57W; Eukaryota.
DR GeneTree; ENSGT00940000154979; -.
DR HOGENOM; CLU_139504_0_0_1; -.
DR InParanoid; Q8IYS8; -.
DR OMA; WNPSVNE; -.
DR OrthoDB; 1333373at2759; -.
DR PhylomeDB; Q8IYS8; -.
DR PathwayCommons; Q8IYS8; -.
DR SignaLink; Q8IYS8; -.
DR BioGRID-ORCS; 284257; 8 hits in 1057 CRISPR screens.
DR GenomeRNAi; 284257; -.
DR Pharos; Q8IYS8; Tdark.
DR PRO; PR:Q8IYS8; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q8IYS8; protein.
DR Bgee; ENSG00000228075; Expressed in sperm and 65 other tissues.
DR Genevisible; Q8IYS8; HS.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000940; C:outer kinetochore; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032515; P:negative regulation of phosphoprotein phosphatase activity; IBA:GO_Central.
DR InterPro; IPR026955; Bod1-like.
DR PANTHER; PTHR31532; PTHR31532; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW Kinetochore; Mitosis; Reference proteome.
FT CHAIN 1..172
FT /note="Biorientation of chromosomes in cell division
FT protein 1-like 2"
FT /id="PRO_0000187033"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 46
FT /note="L -> P (in Ref. 1; BAG54606)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 172 AA; 18075 MW; 6590AAD1F999A6E5 CRC64;
MADGGGGGSG GAGPASTRAS GGGGPINPAS LPPGDPQLIA IIVGQLKSRG LFDSFRRDCK
ADVDTKPAYQ NLSQKADNFV STHLDKQEWN PPANDNQLHD GLRQSVVQSG RSEAGVDRIS
SQVVDPKLNH IFRPQIEQII HEFLVAQKEA AVPALPPEPE GQDPPAPSQD TS
