RUVA_MYCTU
ID RUVA_MYCTU Reviewed; 196 AA.
AC P9WGW3; L0TBQ6; P66744; Q50628;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Holliday junction ATP-dependent DNA helicase RuvA {ECO:0000255|HAMAP-Rule:MF_00031};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00031};
GN Name=ruvA {ECO:0000255|HAMAP-Rule:MF_00031}; OrderedLocusNames=Rv2593c;
GN ORFNames=MTCY227.08;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: The RuvA-RuvB complex in the presence of ATP renatures
CC cruciform structure in supercoiled DNA with palindromic sequence,
CC indicating that it may promote strand exchange reactions in homologous
CC recombination. RuvAB is a helicase that mediates the Holliday junction
CC migration by localized denaturation and reannealing. RuvA stimulates,
CC in the presence of DNA, the weak ATPase activity of RuvB.
CC {ECO:0000255|HAMAP-Rule:MF_00031}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00031};
CC -!- SUBUNIT: Forms a complex with RuvB. {ECO:0000255|HAMAP-Rule:MF_00031}.
CC -!- SIMILARITY: Belongs to the RuvA family. {ECO:0000255|HAMAP-
CC Rule:MF_00031}.
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DR EMBL; AL123456; CCP45389.1; -; Genomic_DNA.
DR PIR; H70726; H70726.
DR RefSeq; NP_217109.1; NC_000962.3.
DR RefSeq; WP_003413421.1; NZ_NVQJ01000023.1.
DR PDB; 2H5X; X-ray; 2.70 A; A/B/C/D=1-196.
DR PDB; 2ZTC; X-ray; 2.80 A; A/B/C/D=1-196.
DR PDB; 2ZTD; X-ray; 2.40 A; A/B=1-196.
DR PDB; 2ZTE; X-ray; 3.20 A; A=1-196.
DR PDBsum; 2H5X; -.
DR PDBsum; 2ZTC; -.
DR PDBsum; 2ZTD; -.
DR PDBsum; 2ZTE; -.
DR AlphaFoldDB; P9WGW3; -.
DR SMR; P9WGW3; -.
DR STRING; 83332.Rv2593c; -.
DR PaxDb; P9WGW3; -.
DR DNASU; 887688; -.
DR GeneID; 45426595; -.
DR GeneID; 887688; -.
DR KEGG; mtu:Rv2593c; -.
DR TubercuList; Rv2593c; -.
DR eggNOG; COG0632; Bacteria.
DR OMA; VGMAVQC; -.
DR PhylomeDB; P9WGW3; -.
DR BRENDA; 3.1.21.10; 3445.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0009379; C:Holliday junction helicase complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009378; F:four-way junction helicase activity; IDA:MTBBASE.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:MTBBASE.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IDA:MTBBASE.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd14332; UBA_RuvA_C; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00031; DNA_helic_RuvA; 1.
DR InterPro; IPR013849; DNA_helicase_Holl-junc_RuvA_I.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR000085; RuvA.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR011114; RuvA_C.
DR InterPro; IPR036267; RuvA_C_sf.
DR Pfam; PF07499; RuvA_C; 1.
DR Pfam; PF01330; RuvA_N; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46929; SSF46929; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00084; ruvA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; DNA damage; DNA recombination; DNA repair;
KW DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW SOS response.
FT CHAIN 1..196
FT /note="Holliday junction ATP-dependent DNA helicase RuvA"
FT /id="PRO_0000094653"
FT STRAND 4..12
FT /evidence="ECO:0007829|PDB:2ZTE"
FT STRAND 14..21
FT /evidence="ECO:0007829|PDB:2ZTE"
FT STRAND 24..29
FT /evidence="ECO:0007829|PDB:2ZTE"
FT HELIX 32..36
FT /evidence="ECO:0007829|PDB:2ZTE"
FT STRAND 42..53
FT /evidence="ECO:0007829|PDB:2ZTE"
FT STRAND 56..63
FT /evidence="ECO:0007829|PDB:2ZTE"
FT HELIX 65..75
FT /evidence="ECO:0007829|PDB:2ZTE"
FT HELIX 82..91
FT /evidence="ECO:0007829|PDB:2ZTE"
FT HELIX 94..103
FT /evidence="ECO:0007829|PDB:2ZTE"
FT HELIX 106..110
FT /evidence="ECO:0007829|PDB:2ZTE"
FT HELIX 117..127
FT /evidence="ECO:0007829|PDB:2ZTE"
FT TURN 128..130
FT /evidence="ECO:0007829|PDB:2ZTE"
SQ SEQUENCE 196 AA; 20189 MW; 40832BC5E1F4756A CRC64;
MIASVRGEVL EVALDHVVIE AAGVGYRVNA TPATLATLRQ GTEARLITAM IVREDSMTLY
GFPDGETRDL FLTLLSVSGV GPRLAMAALA VHDAPALRQV LADGNVAALT RVPGIGKRGA
ERMVLELRDK VGVAATGGAL STNGHAVRSP VVEALVGLGF AAKQAEEATD TVLAANHDAT
TSSALRSALS LLGKAR