BDCR_ECOLI
ID BDCR_ECOLI Reviewed; 197 AA.
AC P39334; P76809; Q2M658;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=HTH-type transcriptional repressor BdcR;
GN Name=bdcR; Synonyms=yjgJ; OrderedLocusNames=b4251, JW4208;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP SEQUENCE REVISION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION AS A REGULATOR, AND GENE NAME.
RC STRAIN=K12 / BW25113;
RX PubMed=21059164; DOI=10.1111/j.1462-2920.2010.02368.x;
RA Ma Q., Yang Z., Pu M., Peti W., Wood T.K.;
RT "Engineering a novel c-di-GMP-binding protein for biofilm dispersal.";
RL Environ. Microbiol. 13:631-642(2011).
CC -!- FUNCTION: Negatively regulates expression of bdcA.
CC {ECO:0000269|PubMed:21059164}.
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DR EMBL; U14003; AAA97147.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAC77208.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78248.1; -; Genomic_DNA.
DR PIR; S56476; S56476.
DR RefSeq; NP_418672.4; NC_000913.3.
DR RefSeq; WP_000256658.1; NZ_LN832404.1.
DR AlphaFoldDB; P39334; -.
DR SMR; P39334; -.
DR BioGRID; 4259559; 174.
DR IntAct; P39334; 1.
DR STRING; 511145.b4251; -.
DR jPOST; P39334; -.
DR PaxDb; P39334; -.
DR PRIDE; P39334; -.
DR EnsemblBacteria; AAC77208; AAC77208; b4251.
DR EnsemblBacteria; BAE78248; BAE78248; BAE78248.
DR GeneID; 948775; -.
DR KEGG; ecj:JW4208; -.
DR KEGG; eco:b4251; -.
DR PATRIC; fig|1411691.4.peg.2453; -.
DR EchoBASE; EB2419; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_28_0_6; -.
DR InParanoid; P39334; -.
DR OMA; HARGYDA; -.
DR PhylomeDB; P39334; -.
DR BioCyc; EcoCyc:G7882-MON; -.
DR PRO; PR:P39334; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..197
FT /note="HTH-type transcriptional repressor BdcR"
FT /id="PRO_0000070647"
FT DOMAIN 15..75
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 38..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 197 AA; 21502 MW; C1E81B87A27435BB CRC64;
MVTKKQSRVP GRPRRFAPEQ AISAAKVLFH QKGFDAVSVA EVTDYLGINP PSLYAAFGSK
AGLFSRVLNE YVGTEAIPLA DILRDDRPVG ECLVEVLKEA ARRYSQNGGC AGCMVLEGIH
SHDPQARDIA VQYYHAAETT IYDYIARRHP QRAQCVTDFM STVMSGLSAK AREGHSIEQL
CATAAMAGEA IKTILEE
