ID   BDEF_ARGIR              Reviewed;         122 AA.
AC   Q0H293;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Big defensin {ECO:0000312|EMBL:ABC61319.1};
DE            Short=AiBD {ECO:0000303|PubMed:16597463};
DE   Flags: Precursor;
OS   Argopecten irradians (Bay scallop) (Aequipecten irradians).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC   Argopecten.
OX   NCBI_TaxID=31199;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABC61319.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=16597463; DOI=10.1016/j.molimm.2006.02.025;
RA   Zhao J., Song L., Li C., Ni D., Wu L., Zhu L., Wang H., Xu W.;
RT   "Molecular cloning, expression of a big defensin gene from bay scallop
RT   Argopecten irradians and the antimicrobial activity of its recombinant
RT   protein.";
RL   Mol. Immunol. 44:360-368(2007).
CC   -!- FUNCTION: Significantly inhibits the growth of Gram-negative and Gram-
CC       positive bacteria and fungi in vitro. {ECO:0000269|PubMed:16597463}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16597463}.
CC   -!- TISSUE SPECIFICITY: Expressed in hemocytes.
CC       {ECO:0000269|PubMed:16597463}.
CC   -!- SIMILARITY: Belongs to the big defensin family. {ECO:0000305}.
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DR   EMBL; DQ334340; ABC61319.1; -; mRNA.
DR   AlphaFoldDB; Q0H293; -.
DR   SMR; Q0H293; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   Gene3D; 3.40.1620.80; -; 1.
DR   InterPro; IPR028060; Defensin_big_dom.
DR   InterPro; IPR042033; Defensin_big_N.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   Pfam; PF14862; Defensin_big; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW   Disulfide bond; Fungicide; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   PROPEP          29..34
FT                   /evidence="ECO:0000250|UniProtKB:P80957, ECO:0000255"
FT                   /id="PRO_0000379965"
FT   CHAIN           39..122
FT                   /note="Big defensin"
FT                   /evidence="ECO:0000250|UniProtKB:P80957, ECO:0000255"
FT                   /id="PRO_0000379966"
FT   DISULFID        88..119
FT                   /evidence="ECO:0000250|UniProtKB:P80957"
FT   DISULFID        95..114
FT                   /evidence="ECO:0000250|UniProtKB:P80957"
FT   DISULFID        99..120
FT                   /evidence="ECO:0000250|UniProtKB:P80957"
SQ   SEQUENCE   122 AA;  13650 MW;  65D9FCFEDC3A2875 CRC64;
     MTRPSLVRCY SLFFTALIVM AIICPAWSEE IPKSRKKRAI PIAYVGMAVA PQVFRWLVRA
     YGAAAVTAAG VTLRRVINRS RSNDNHSCYG NRGWCRSSCR SYEREYRGGN LGVCGSYKCC
     VT