ID   BDEF_BRABE              Reviewed;         117 AA.
AC   Q86QN6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Big defensin {ECO:0000250|UniProtKB:P80957};
DE   AltName: Full=Defensin {ECO:0000312|EMBL:AAO18674.1};
DE   Flags: Precursor;
OS   Branchiostoma belcheri (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7741;
RN   [1] {ECO:0000312|EMBL:AAO18674.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Subsp. tsingtauense;
RA   Zhang S., Liu Z., Liu M., Xu A.;
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Significantly inhibits the growth of Gram-negative and Gram-
CC       positive bacteria and fungi in vitro. {ECO:0000250|UniProtKB:P80957}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P80957}.
CC   -!- SIMILARITY: Belongs to the big defensin family. {ECO:0000305}.
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DR   EMBL; AY175378; AAO18674.1; -; mRNA.
DR   AlphaFoldDB; Q86QN6; -.
DR   SMR; Q86QN6; -.
DR   Proteomes; UP000515135; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; ISS:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   Gene3D; 3.40.1620.80; -; 1.
DR   InterPro; IPR028060; Defensin_big_dom.
DR   InterPro; IPR042033; Defensin_big_N.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   Pfam; PF14862; Defensin_big; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW   Disulfide bond; Fungicide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..33
FT                   /evidence="ECO:0000250|UniProtKB:P80957, ECO:0000255"
FT                   /id="PRO_0000379967"
FT   CHAIN           36..117
FT                   /note="Big defensin"
FT                   /evidence="ECO:0000250|UniProtKB:P80957, ECO:0000255"
FT                   /id="PRO_0000379968"
FT   DISULFID        82..112
FT                   /evidence="ECO:0000250|UniProtKB:P80957"
FT   DISULFID        89..107
FT                   /evidence="ECO:0000250|UniProtKB:P80957"
FT   DISULFID        93..113
FT                   /evidence="ECO:0000250|UniProtKB:P80957"
SQ   SEQUENCE   117 AA;  12914 MW;  25431554DC0D20EA CRC64;
     MEKKTAYCLL FLVLLVPYTA LGAVLKRAPA KKEKRAVPLA VPLVYWGASV SPAVWNWLLV
     TFGAAAVAAA AVTVSDNDSH SCANNRGWCR SRCFSHEYID SWHSDVCGSY DCCRPRY