ID   BDEF_RUDPH              Reviewed;          11 AA.
AC   P86316;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Big defensin {ECO:0000303|PubMed:14673509};
DE            Short=RPD-1 {ECO:0000303|PubMed:14673509};
DE   Flags: Fragment;
OS   Ruditapes philippinarum (Japanese littleneck clam) (Venerupis
OS   philippinarum).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Heteroconchia; Euheterodonta; Imparidentia; Neoheterodontei;
OC   Venerida; Veneroidea; Veneridae; Ruditapes.
OX   NCBI_TaxID=129788;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=14673509;
RA   Wei Y.-X., Guo D.-S., Li R.-G., Chen H.-W., Chen P.-X.;
RT   "Purification of a big defensin from Ruditapes philippinesis and its
RT   antibacterial activity.";
RL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:1145-1148(2003).
CC   -!- FUNCTION: Significantly inhibits the growth of Gram-negative and Gram-
CC       positive bacteria and fungi in vitro. Has antibacterial activity
CC       against S.aureus (MIC=9.6 mg/L), B.subtilis (MIC=76.8 mg/L),
CC       M.tetragenus (MIC=38.4 mg/L), E.coli (MIC=76.8 mg/L),
CC       V.parahaemolyticus (MIC=19.2 mg/L), and V.anguillarum (MIC=2.1 mg/L).
CC       {ECO:0000269|PubMed:14673509}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14673509}.
CC   -!- SIMILARITY: Belongs to the big defensin family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing; Fungicide;
KW   Secreted.
FT   CHAIN           1..>11
FT                   /note="Big defensin"
FT                   /id="PRO_0000379969"
FT   NON_TER         11
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   11 AA;  1123 MW;  993983D149CDC2CA CRC64;
     AVPDVAFNAY G