BDGED_DROME
ID BDGED_DROME Reviewed; 1331 AA.
AC Q0E961; A0A0B4LF97;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Sodium-dependent transporter bedraggled {ECO:0000303|PubMed:17890365};
GN Name=bdg {ECO:0000303|PubMed:17890365, ECO:0000312|FlyBase:FBgn0034049};
GN ORFNames=CG8291 {ECO:0000312|FlyBase:FBgn0034049};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AHB32098.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AHB32098.1};
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=17890365; DOI=10.1534/genetics.107.075945;
RA Rawls A.S., Schultz S.A., Mitra R.D., Wolff T.;
RT "Bedraggled, a putative transporter, influences the tissue polarity complex
RT during the R3/R4 fate decision in the Drosophila eye.";
RL Genetics 177:313-328(2007).
CC -!- FUNCTION: Putative sodium-dependent transporter which is required for
CC viability, early imaginal disk development and adult motor coordination
CC (PubMed:17890365). Also has a role in the fate commitment of the R3/R4
CC photoreceptor cells (PubMed:17890365). May function in ommatidial
CC polarity by regulating the activity of the core polarity genes, acting
CC upstream of (or in parallel to) Vang, dsh, pk, stan, and dgo, but
CC downstream or independently of fz (PubMed:17890365).
CC {ECO:0000269|PubMed:17890365}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: Expressed in third instar eye disks.
CC {ECO:0000269|PubMed:17890365}.
CC -!- DISRUPTION PHENOTYPE: The imaginal disks of third instar larvae are
CC dramatically decreased in size (PubMed:17890365). Overall larval size
CC is unaffected (PubMed:17890365). {ECO:0000269|PubMed:17890365}.
CC -!- MISCELLANEOUS: The name 'bedraggled' derives from escaper mutant adults
CC which upon eclosion, immediately fall into their food and die due to
CC severe defects in motor coordination. {ECO:0000303|PubMed:17890365}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
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DR EMBL; AE013599; AAF58096.2; -; Genomic_DNA.
DR EMBL; AE013599; AAM70967.2; -; Genomic_DNA.
DR EMBL; AE013599; AAO41388.1; -; Genomic_DNA.
DR EMBL; AE013599; AHN56266.1; -; Genomic_DNA.
DR EMBL; BT150416; AHB32098.1; -; mRNA.
DR RefSeq; NP_001286469.1; NM_001299540.1.
DR RefSeq; NP_611064.2; NM_137220.3.
DR RefSeq; NP_725499.2; NM_166121.2.
DR RefSeq; NP_788361.1; NM_176181.2.
DR AlphaFoldDB; Q0E961; -.
DR IntAct; Q0E961; 4.
DR STRING; 7227.FBpp0086433; -.
DR GlyGen; Q0E961; 5 sites.
DR PaxDb; Q0E961; -.
DR PRIDE; Q0E961; -.
DR EnsemblMetazoa; FBtr0087298; FBpp0086433; FBgn0034049.
DR EnsemblMetazoa; FBtr0087299; FBpp0086434; FBgn0034049.
DR EnsemblMetazoa; FBtr0087300; FBpp0086435; FBgn0034049.
DR EnsemblMetazoa; FBtr0340017; FBpp0309031; FBgn0034049.
DR GeneID; 36747; -.
DR KEGG; dme:Dmel_CG8291; -.
DR UCSC; CG8291-RA; d. melanogaster.
DR CTD; 36747; -.
DR FlyBase; FBgn0034049; bdg.
DR VEuPathDB; VectorBase:FBgn0034049; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_256149_0_0_1; -.
DR InParanoid; Q0E961; -.
DR OMA; QCTKMSS; -.
DR OrthoDB; 73798at2759; -.
DR PhylomeDB; Q0E961; -.
DR SignaLink; Q0E961; -.
DR BioGRID-ORCS; 36747; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36747; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034049; Expressed in adult hindgut (Drosophila) and 29 other tissues.
DR ExpressionAtlas; Q0E961; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; ISS:FlyBase.
DR GO; GO:0005328; F:neurotransmitter:sodium symporter activity; ISM:FlyBase.
DR GO; GO:0006836; P:neurotransmitter transport; ISS:FlyBase.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1331
FT /note="Sodium-dependent transporter bedraggled"
FT /id="PRO_0000452842"
FT TRANSMEM 505..525
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 531..551
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 667..687
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 696..716
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 741..761
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 778..798
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 890..910
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 926..946
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 956..976
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 998..1018
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 1044..1064
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 627
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 631
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 857
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 921
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 667
FT /note="Missing (in Ref. 1; AHN56266)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1331 AA; 146659 MW; D89EAE2EBD7CA461 CRC64;
MSSKEQQAAG RDFKRNSNAY SSLPPTGTGA GCSGAALGSG TGTGKRARSK QHQLEHEQFG
LSNSLSSESI RQACAYYDDE LSDEDLIEIQ QTPQAFHQQT KQPLQLQPIS FRLGDELGDE
RSAFCGSQEM QQVPLSTPIK QAAETDEALC VLSELDAILD VHDVSQLNGT CSSGSVNSGS
DDDKVEDYLM DLDNYLEEMD NALNREDSLI IIDGHTSLKR EPRTRTLPLS RKKKSSKKKS
EDQEAAQGDF QREHQLRKTF SCSLRPTSQI ASSSGSLETS TEPVMDVWRR QSMRRALEQE
DTKATVAMER EEDDIPTLLV ELPPRRDAEM RRCFSQGDCQ ASVAPTVGSQ MLTEAHIFDN
LLQTNARASS EEPRPRQYGR RLEGPPTPVR PLILAQSRPQ SAPTRVQMRE PQLQDTPTHP
IMSTCSELSS ARSSRMPSPV SLPSDSSSSG SSSAEHDQEP DPVQTTTMCS ASSTTPLEPL
HQLQLLLREK CGFNSQWPHA GSRTLALIGC TLGVFNMCRF AVLTINFGGN FLLQFLLLSV
IFGIPLLWLQ MCLGAKIRAG PVSMWKISPI CAGVGIALVM QQCFLALYST VSLAWILVYL
RDVFPTAARS GYRWQEMAFP YRYDASNATG NLTQTVAEYF NVVVLQRLHL ANHPDASGIR
FHVNDRQLAF YLALIWAAVF LILCKGLKSL GKLAYIIYTL PLVALAVVTA KFVYVVDPSR
IQNIFAASDF DDFLVNSNSW TAATQETFLT WGLLGASVIA ITSRSHTNAN KAALRRDAIL
LVLFTLIGLG LMALLALCCA QILWQHGYVY VPGSFENPDC YTSIYSLQSN TNPYLLSYPR
SLIPHYSSFI GETYRRNRTM IHVESGFQAL RFISEIFPAV LSLASDSISW VWAAVAFATF
AGFGLAQLCV MWKPISSALG NSTSSVLLSC VTGLLLSIPF ATEMGISILY YVDFLLGGSW
FIPIIWTAQI FGVFLIRGRP YNGDDLVNDL RLCGSMSAFL ALSWNVLLPI GLITLSVVDY
KASLSNQFYY WRGKSYFTYW SRKMGSLIQI GVLLVIPVTA IIQIYRYLAH GPPDILERIQ
LLYRPPEEGE EPRRPSARQT ASQSRRNALG QTTEGGQHDA QNDAPPKYTP PPSYTTATGA
RLAKLLRQSI RRSVRRVLGD SSRTRPVLSL DAESASPAAP PDYLTILTNP AGSSFNADPS
PASSSSPESI EIDQRPVGYS QRSQSLGRKL HRSGASTLER RPYTAEDVVT ILRSSVRHRQ
SQGGGNLVTA STLPRPPTAA MSTHLEDASF RSIENLVLNA EPPDRTPGVE LELELEAGQA
EECARNNTSV I
