ABCG4_DICDI
ID ABCG4_DICDI Reviewed; 798 AA.
AC Q8T689; Q54H75;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=ABC transporter G family member 4;
DE AltName: Full=ABC transporter ABCG.4;
GN Name=abcG4; ORFNames=DDB_G0289657;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; AF482383; AAL91489.1; -; Genomic_DNA.
DR EMBL; AAFI02000148; EAL62540.1; -; Genomic_DNA.
DR RefSeq; XP_636043.1; XM_630951.1.
DR AlphaFoldDB; Q8T689; -.
DR SMR; Q8T689; -.
DR STRING; 44689.DDB0216252; -.
DR PaxDb; Q8T689; -.
DR EnsemblProtists; EAL62540; EAL62540; DDB_G0289657.
DR GeneID; 8627253; -.
DR KEGG; ddi:DDB_G0289657; -.
DR dictyBase; DDB_G0289657; abcG4.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q8T689; -.
DR OMA; IRIAMYM; -.
DR PhylomeDB; Q8T689; -.
DR Reactome; R-DDI-189451; Heme biosynthesis.
DR Reactome; R-DDI-189483; Heme degradation.
DR Reactome; R-DDI-917937; Iron uptake and transport.
DR Reactome; R-DDI-9753281; Paracetamol ADME.
DR PRO; PR:Q8T689; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IGC:dictyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..798
FT /note="ABC transporter G family member 4"
FT /id="PRO_0000391393"
FT TRANSMEM 540..560
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 656..676
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 713..733
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 771..791
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 211..464
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 540..793
FT /note="ABC transmembrane type-2"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 34..83
FT /evidence="ECO:0000255"
FT COMPBIAS 8..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 253..260
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 798 AA; 90834 MW; 92E51144968A7FFF CRC64;
MEDIGNNNFE IIDDKSDEKN DENFEDKNSR NNINEEQILS NQQQQQQQQQ QQQQQQQQQQ
QQQQQQQQQQ QEQQQFKNEV INTLHPKQPN NEYSLSSLSL SPQTPQINLS EKLISDNSNL
NSNSNNNNKD IESGIQTKIK NIENRRNSIN SDSSGTFNNE ITNGRSNDNE IININNNVGV
QVTFENICYK VLNKKYNEQK KIIKKLESGK IDIEDIESQV NKLPIDRIIE KELTILSNVS
GIVEKGEMVA LMGPSGSGKS TLLDILANRK STGTITGKIL VNGKEIGEAY KMFCSYVTQE
EVFLETSTVY ETLKFHADLR LPDMTDTEKD IRIKQVLKDV GLDRKLNSKI GGILPGGMIV
KGLSGGEKKR VSIGCALVTN PSLLFLDEPT SGLDSLNSLK VMKVLLELTK MKGVTVVCSV
HQPRPEIFYL FSNIMVVLKG RMVYSGSNIL EYLSSIDSNY KCPPQMNPAD FILDVCDEIV
NNPSQYSTTV DTWEKYWKHE IQPTISNDPI NIDIPKRVGF IYQYWVCQKR SYQSFVRNRV
VFFSKIVIAI LIGLLFSACF GTVGYDGLDQ NEAQSVSALF FFIITSLNLL PYSSISTFVS
IRTLFNSERA SKIYHPFPYF IGSMLIEIVS SFFVVLIITT IIYCIVHLRW SFEAYILSLI
SFYMVFLASV FMVIAMSNIA GTVDLTFSYC TGVSVVLVLF SGFLVPINSL PDSFGWIHHI
DYLFYGFSSI VIIQYRDFEF QCPQPPIPCL YSNGNNLIEF LGLKNWEYNK SIGILTIWIA
FFYILAYIGL YKFNKEKR
