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RUVB1_AEDAE
ID   RUVB1_AEDAE             Reviewed;         456 AA.
AC   Q0IFL2;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=RuvB-like helicase 1;
DE            EC=3.6.4.12;
DE   AltName: Full=Pontin;
GN   Name=pont {ECO:0000250|UniProtKB:Q9VH07}; ORFNames=AAEL004686;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT43892.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Acts as a transcriptional coactivator in Wg signaling.
CC       {ECO:0000250}.
CC   -!- FUNCTION: Proposed core component of the chromatin remodeling Ino80
CC       complex which is involved in transcriptional regulation, DNA
CC       replication and probably DNA repair. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBUNIT: Forms homohexameric rings. May form a dodecamer with rept made
CC       of two stacked hexameric rings. Component of the chromatin remodeling
CC       Ino80 complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VH07}.
CC   -!- SIMILARITY: Belongs to the RuvB family. {ECO:0000305}.
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DR   EMBL; CH477312; EAT43892.1; -; Genomic_DNA.
DR   RefSeq; XP_001649604.1; XM_001649554.1.
DR   AlphaFoldDB; Q0IFL2; -.
DR   SMR; Q0IFL2; -.
DR   STRING; 7159.AAEL004686-PA; -.
DR   GeneID; 5565268; -.
DR   KEGG; aag:5565268; -.
DR   VEuPathDB; VectorBase:AAEL004686; -.
DR   eggNOG; KOG1942; Eukaryota.
DR   HOGENOM; CLU_028311_1_1_1; -.
DR   InParanoid; Q0IFL2; -.
DR   OMA; VIYVEAN; -.
DR   OrthoDB; 752343at2759; -.
DR   PhylomeDB; Q0IFL2; -.
DR   Proteomes; UP000008820; Chromosome 1.
DR   GO; GO:0031011; C:Ino80 complex; IEA:InterPro.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0097255; C:R2TP complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   Gene3D; 2.40.50.360; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR027238; RuvB-like.
DR   InterPro; IPR041048; RuvB-like_C.
DR   InterPro; IPR037938; RUVBL1.
DR   InterPro; IPR042487; RuvBL1/2_DNA/RNA_bd_dom.
DR   InterPro; IPR010339; TIP49_P-loop.
DR   PANTHER; PTHR11093; PTHR11093; 1.
DR   PANTHER; PTHR11093:SF6; PTHR11093:SF6; 1.
DR   Pfam; PF06068; TIP49; 1.
DR   Pfam; PF17856; TIP49_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Activator; ATP-binding; Cell cycle; Cell division; Chromatin regulator;
KW   DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..456
FT                   /note="RuvB-like helicase 1"
FT                   /id="PRO_0000306319"
FT   BINDING         70..77
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y230"
SQ   SEQUENCE   456 AA;  50173 MW;  3BBC1FFB61864ABB CRC64;
     MKIEEVKSTV KTQRIAAHSH VKGLGLDENG VPLQMAAGLV GQKDAREAAG IVVDLIKSKK
     MSGRALLLAG PPGTGKTAIA LAIAQELGNK VPFCPMVGSE VFSSEIKKTE VLMENFRRSI
     GLRIRETKEV YEGEVTELTP VETENPMGGY GKTISNVVIG LKTAKGTKQL KLDPSIYESL
     QKEKVEVGDV IYIEANSGAV KRQGRSDTFA TEFDLETEEY VPLPKGDVHK KKEVVQDVTL
     HDLDVANARP QGGQDVLSMV GQIMKPKKTE ITDKLRMEIN KVVNKYIDQG IAELVPGVLF
     IDEVHMLDLE CFTYLHKSLE SAIAPIVIFA TNRGRCVIRG TDDIISPHGI PLDLLDRLLI
     VRTAPYNLSE IEQIIKLRAQ TEGLSVEDSA IQALSEIGDN TTLRYAVQLL TPAHQNCKVN
     GRTQITKDDI VEVNGLFLDA KRSAKFLQEE NTKYMM
 
 
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