RUVB1_CANGA
ID RUVB1_CANGA Reviewed; 457 AA.
AC Q6FU78;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=RuvB-like helicase 1;
DE EC=3.6.4.12;
GN Name=RVB1; OrderedLocusNames=CAGL0F05643g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: DNA helicase which participates in several chromatin
CC remodeling complexes, including the SWR1 and the INO80 complexes. The
CC SWR1 complex mediates the ATP-dependent exchange of histone H2A for the
CC H2A variant HZT1 leading to transcriptional regulation of selected
CC genes by chromatin remodeling. The INO80 complex remodels chromatin by
CC shifting nucleosomes and is involved in DNA repair. Also involved in
CC pre-rRNA processing (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBUNIT: May form heterododecamers with RVB2. Component of the SWR1
CC chromatin remodeling complex, the INO80 chromatin remodeling complex,
CC and of the R2TP complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RuvB family. {ECO:0000305}.
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DR EMBL; CR380952; CAG59140.1; -; Genomic_DNA.
DR RefSeq; XP_446216.1; XM_446216.1.
DR AlphaFoldDB; Q6FU78; -.
DR SMR; Q6FU78; -.
DR STRING; 5478.XP_446216.1; -.
DR EnsemblFungi; CAG59140; CAG59140; CAGL0F05643g.
DR GeneID; 2887725; -.
DR KEGG; cgr:CAGL0F05643g; -.
DR CGD; CAL0129272; CAGL0F05643g.
DR VEuPathDB; FungiDB:CAGL0F05643g; -.
DR eggNOG; KOG1942; Eukaryota.
DR HOGENOM; CLU_028311_1_1_1; -.
DR InParanoid; Q6FU78; -.
DR OMA; VIYVEAN; -.
DR Proteomes; UP000002428; Chromosome F.
DR GO; GO:0070209; C:ASTRA complex; IEA:EnsemblFungi.
DR GO; GO:0031011; C:Ino80 complex; IEA:EnsemblFungi.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0097255; C:R2TP complex; IEA:EnsemblFungi.
DR GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:EnsemblFungi.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0000492; P:box C/D snoRNP assembly; IEA:EnsemblFungi.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR Gene3D; 2.40.50.360; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027238; RuvB-like.
DR InterPro; IPR041048; RuvB-like_C.
DR InterPro; IPR037938; RUVBL1.
DR InterPro; IPR042487; RuvBL1/2_DNA/RNA_bd_dom.
DR InterPro; IPR010339; TIP49_P-loop.
DR PANTHER; PTHR11093; PTHR11093; 1.
DR PANTHER; PTHR11093:SF6; PTHR11093:SF6; 1.
DR Pfam; PF06068; TIP49; 1.
DR Pfam; PF17856; TIP49_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW Activator; ATP-binding; Chromatin regulator; DNA damage; DNA repair;
KW Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..457
FT /note="RuvB-like helicase 1"
FT /id="PRO_0000165651"
FT BINDING 73..80
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 457 AA; 49849 MW; 02EDEC8023A5A3AB CRC64;
MVQITEVNES KAGTANRTAA HTHIKGLGLD DTGAARQVEG GFVGQVEARE ACGVIVDLIK
AKKMSGRAIL LAGGPSTGKT ALALAISQEL GPKVPFCPLV GSELYSVEVK KTETLMENFR
RAIGLRIKET KEVYEGEVTE LTPEDAENPL GGYGKTISHV IVGLKSAKGT KTLRLDPTIY
DSIQKEKVSI GDVIYIEANT GAVKRVGRSD AYATEFDLEA EEYVPLPKGE VHKKKEIVQD
VTLHDLDIAN ARPQGGQDVI SMMGQLMKPK KTEITEKLRF EVNKVVAKYV DQGVAELIPG
VLFIDEANML DIEIFTYLNK ALESDIAPIV VLASNRGMTT VRGTEDVISP HGIPADLIDR
LLIVRTLPYN KDEIRLIIER RSAVENLALE DGALDILADM ATHTSLRYAL QLLSPAGILS
STAGRQKITI DDINEAKMLF IDAKRSTKIL ENSDRYM
