RUVB1_DROPS
ID RUVB1_DROPS Reviewed; 456 AA.
AC Q29AK9;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=RuvB-like helicase 1;
DE EC=3.6.4.12;
DE AltName: Full=Pontin;
GN Name=pont {ECO:0000250|UniProtKB:Q9VH07}; ORFNames=GA17841;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL27340.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Acts as a transcriptional coactivator in Wg signaling caused
CC by altered arm signaling. Pont and rept interfere antagonistically with
CC nuclear arm signaling function, and are required to enhance or reduce
CC arm activity, respectively. Also an essential cofactor for the normal
CC function of Myc; required for cellular proliferation and growth (By
CC similarity). {ECO:0000250|UniProtKB:Q9VH07}.
CC -!- FUNCTION: Proposed core component of the chromatin remodeling Ino80
CC complex which is involved in transcriptional regulation, DNA
CC replication and probably DNA repair. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBUNIT: Forms homohexameric rings. May form a dodecamer with rept made
CC of two stacked hexameric rings (By similarity). Component of the
CC chromatin remodeling Ino80 complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VH07}.
CC -!- SIMILARITY: Belongs to the RuvB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL27340.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CM000070; EAL27340.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001358203.1; XM_001358166.4.
DR AlphaFoldDB; Q29AK9; -.
DR SMR; Q29AK9; -.
DR STRING; 7237.FBpp0282480; -.
DR EnsemblMetazoa; FBtr0284042; FBpp0282480; FBgn0077850.
DR GeneID; 4801035; -.
DR KEGG; dpo:Dpse_GA17841; -.
DR eggNOG; KOG1942; Eukaryota.
DR HOGENOM; CLU_028311_1_1_1; -.
DR InParanoid; Q29AK9; -.
DR OMA; VIYVEAN; -.
DR PhylomeDB; Q29AK9; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0077850; Expressed in female reproductive system and 3 other tissues.
DR GO; GO:0035060; C:brahma complex; IEA:EnsemblMetazoa.
DR GO; GO:0031011; C:Ino80 complex; IEA:EnsemblMetazoa.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0097255; C:R2TP complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016573; P:histone acetylation; IEA:EnsemblMetazoa.
DR GO; GO:0043486; P:histone exchange; IEA:EnsemblMetazoa.
DR GO; GO:0090307; P:mitotic spindle assembly; IEA:EnsemblMetazoa.
DR GO; GO:0060548; P:negative regulation of cell death; IEA:EnsemblMetazoa.
DR GO; GO:0046329; P:negative regulation of JNK cascade; IEA:EnsemblMetazoa.
DR GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR Gene3D; 2.40.50.360; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027238; RuvB-like.
DR InterPro; IPR041048; RuvB-like_C.
DR InterPro; IPR037938; RUVBL1.
DR InterPro; IPR042487; RuvBL1/2_DNA/RNA_bd_dom.
DR InterPro; IPR010339; TIP49_P-loop.
DR PANTHER; PTHR11093; PTHR11093; 1.
DR PANTHER; PTHR11093:SF6; PTHR11093:SF6; 1.
DR Pfam; PF06068; TIP49; 1.
DR Pfam; PF17856; TIP49_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW Activator; ATP-binding; Cell cycle; Cell division; Chromatin regulator;
KW DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase;
KW Nucleotide-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..456
FT /note="RuvB-like helicase 1"
FT /id="PRO_0000306321"
FT BINDING 70..77
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:Q9Y230"
SQ SEQUENCE 456 AA; 50159 MW; 679C091AF0BA6C8C CRC64;
MKIEEVKSTV RTQRIAAHSH VKGLGLDEAG SALQSAAGLV GQKAAREAAG IVVDLIKSKK
MAGRALLLAG PPGTGKTAIA LAIAQELGNK VPFCPMVGSE VFSNEIKKTE VLMENFRRSI
GLRIRETKEV YEGEVTELTP VETENPMGGY GKTISNVVIG LKTAKGTKQL KLDPSIFDAL
QKEKVEVGDV IYIEANSGAV KRQGRSDTFA TEFDLETEEY VPLPKGDVHK KKEVIQDVTL
HDLDVANARP QGGQDVLSMV GQLMKPKKTE ITDKLRMEIN KVVNKYIDQG IAELVPGVLF
IDEIHMLDLE TFTYLHKSLE SPIAPIVIFA TNRGRCVIRG TTDIVSPHGI PLDLLDRLLI
IRTLLYSTSD MEQIIKLRAQ TEGLQLEDPA FARLSEIGTS STLRYAVQLL TPAHQMCKVN
GRTQITKDDI EDVHSLFLDA KRSSKHLSEK NNKFML
