RUVB2_DROPS
ID RUVB2_DROPS Reviewed; 480 AA.
AC Q29DI0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=RuvB-like helicase 2;
DE EC=3.6.4.12;
DE AltName: Full=Reptin;
GN Name=rept {ECO:0000250|UniProtKB:Q9V3K3}; ORFNames=GA22008;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL30434.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Acts as a transcriptional coactivator in Wg signaling caused
CC by altered arm signaling. Pont and rept interfere antagonistically with
CC nuclear arm signaling function, and are required to enhance or reduce
CC arm activity, respectively. Also an essential cofactor for the normal
CC function of Myc; required for cellular proliferation and growth (By
CC similarity). {ECO:0000250}.
CC -!- FUNCTION: Proposed core component of the chromatin remodeling Ino80
CC complex which is involved in transcriptional regulation, DNA
CC replication and probably DNA repair. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBUNIT: Forms homohexameric rings. May form a dodecamer with rept made
CC of two stacked hexameric rings. Component of the chromatin remodeling
CC Ino80 complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9V3K3}.
CC -!- SIMILARITY: Belongs to the RuvB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL30434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH379070; EAL30434.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001352933.1; XM_001352897.3.
DR AlphaFoldDB; Q29DI0; -.
DR SMR; Q29DI0; -.
DR STRING; 7237.FBpp0287044; -.
DR EnsemblMetazoa; FBtr0288606; FBpp0287044; FBgn0081993.
DR GeneID; 4812022; -.
DR KEGG; dpo:Dpse_GA22008; -.
DR eggNOG; KOG2680; Eukaryota.
DR HOGENOM; CLU_028311_4_0_1; -.
DR InParanoid; Q29DI0; -.
DR OMA; YDMGAKM; -.
DR PhylomeDB; Q29DI0; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0081993; Expressed in female reproductive system and 3 other tissues.
DR GO; GO:0031011; C:Ino80 complex; IEA:EnsemblMetazoa.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0097255; C:R2TP complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0035072; P:ecdysone-mediated induction of salivary gland cell autophagic cell death; IEA:EnsemblMetazoa.
DR GO; GO:0031507; P:heterochromatin assembly; IEA:EnsemblMetazoa.
DR GO; GO:0016573; P:histone acetylation; ISS:UniProtKB.
DR GO; GO:0043486; P:histone exchange; ISS:UniProtKB.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:EnsemblMetazoa.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR Gene3D; 2.40.50.360; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027238; RuvB-like.
DR InterPro; IPR041048; RuvB-like_C.
DR InterPro; IPR042487; RuvBL1/2_DNA/RNA_bd_dom.
DR InterPro; IPR037942; RUVBL2.
DR InterPro; IPR010339; TIP49_P-loop.
DR PANTHER; PTHR11093; PTHR11093; 1.
DR PANTHER; PTHR11093:SF2; PTHR11093:SF2; 1.
DR Pfam; PF06068; TIP49; 1.
DR Pfam; PF17856; TIP49_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chromatin regulator; DNA damage; DNA repair; Helicase;
KW Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..480
FT /note="RuvB-like helicase 2"
FT /id="PRO_0000306324"
FT BINDING 73..80
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:Q9Y230"
SQ SEQUENCE 480 AA; 53541 MW; 8B0E4D7A57FC71E5 CRC64;
MTEAEKIEVR DITRIERIGA HSHIRGLGLD DVLEARAVSQ GMVGQKDARR AAGVVVQMVR
EGKIAGRCIL LAGEPSTGKT AIAVGMAQAL GTETPFTSMS GSEIYSLEMS KTEALSQALR
KSIGVRIKEE TEIIEGEVVE IQIERPATGT GQKVGKVTLK TTEMETNYDL GNKIIECFMK
EKIQAGDVIT IDKASGKVNK LGRSFTRARD YDATGAQTRF VQCPEGELQK RKEVVHTVTL
HEIDVINSRT HGFLALFSGD TGEIKQEVRD QINNKVLEWR EEGKAEINPG VLFIDEVHML
DIECFSYLNR ALESDMAPVV VMATNRGITR IRGTNYRSPH GIPIDLLDRM IIIRTVPYSE
KEVKEILKIR CEEEDCVMHP DALTILTRIA TDTSLRYAIQ LITTANLVCR RRKATEVNTE
DVKKVYSLFL DENRSSKILK EYQDDYMFSE ITEKEEDFGI GGGSKRRLDI GAGDAEAMEH
