BDLA_PSEAE
ID BDLA_PSEAE Reviewed; 417 AA.
AC Q9I3S1;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Biofilm dispersion protein BdlA;
DE AltName: Full=Chemotaxis regulator BdlA;
GN Name=bdlA; OrderedLocusNames=PA1423;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP FUNCTION IN BIOFILM DISPERSION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=17050921; DOI=10.1128/jb.00599-06;
RA Morgan R., Kohn S., Hwang S.-H., Hassett D.J., Sauer K.;
RT "BdlA, a chemotaxis regulator essential for biofilm dispersion in
RT Pseudomonas aeruginosa.";
RL J. Bacteriol. 188:7335-7343(2006).
CC -!- FUNCTION: Essential for biofilm dispersion by sensing environmental
CC cues. May be involved in sensing and transducing signals within cells,
CC resulting in the modulation of c-di-GMP levels, swimming motility and
CC adhesiveness of the bacterial cell surface.
CC {ECO:0000269|PubMed:17050921}.
CC -!- DISRUPTION PHENOTYPE: Cells are named mutant biofilms and do not
CC disperse upon induction of the dispersion by succinate, silver nitrate,
CC mercury chloride or sodium arsenate. They are resistant to hydrogen
CC peroxide and more hydrophobic. They show higher intracellular levels of
CC c-di-GMP (5- to 6-fold higher than in wild-type), increased adherent
CC properties and impaired twitching motility. They display smaller,
CC densely packed and symmetrical microcolonies.
CC {ECO:0000269|PubMed:17050921}.
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DR EMBL; AE004091; AAG04812.1; -; Genomic_DNA.
DR PIR; B83469; B83469.
DR RefSeq; NP_250114.1; NC_002516.2.
DR RefSeq; WP_003082971.1; NZ_QZGE01000005.1.
DR AlphaFoldDB; Q9I3S1; -.
DR SMR; Q9I3S1; -.
DR IntAct; Q9I3S1; 2.
DR STRING; 287.DR97_600; -.
DR PaxDb; Q9I3S1; -.
DR EnsemblBacteria; AAG04812; AAG04812; PA1423.
DR GeneID; 881734; -.
DR KEGG; pae:PA1423; -.
DR PATRIC; fig|208964.12.peg.1472; -.
DR PseudoCAP; PA1423; -.
DR HOGENOM; CLU_000445_107_26_6; -.
DR InParanoid; Q9I3S1; -.
DR OMA; IWIQAAY; -.
DR PhylomeDB; Q9I3S1; -.
DR BioCyc; PAER208964:G1FZ6-1449-MON; -.
DR PHI-base; PHI:3041; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd00130; PAS; 2.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR004089; MCPsignal_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR Pfam; PF00015; MCPsignal; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00283; MA; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; SSF55785; 2.
DR TIGRFAMs; TIGR00229; sensory_box; 2.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Transducer.
FT CHAIN 1..417
FT /note="Biofilm dispersion protein BdlA"
FT /id="PRO_0000262581"
FT DOMAIN 1..66
FT /note="PAS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 67..114
FT /note="PAC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00141"
FT DOMAIN 115..188
FT /note="PAS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 191..241
FT /note="PAC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00141"
FT DOMAIN 242..417
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
SQ SEQUENCE 417 AA; 46923 MW; 266F998AA359843E CRC64;
MAALDRSMAR VEFDPDGNIT DANENFLTLL GYRRDEILGK PHRQLCDGAY AQSEDYRRFW
ERLRRGEHFS GRCKRITREG RPLWLEATYN PVRDGQGRLL KVVKYASDID AIVHQEHEMQ
SKLDALSRSM AMIEFDLDGN VLAANDNFLA TMGYGRAELA SANHRQFCEP GYRDGPQYAD
LWRRLNRGEY VTGQFRRVHR NGQPVWLEAS YNPVYDADGK LYKVVKFASD VSDRMRRYQA
EADNAHQAHT LSTETRTVAE HGALIIQSAV EEMLKIANTL DASSLNIGEL SQHSQQITSI
VNTIREIAEQ TNLLALNAAI EAARAGDQGR GFAVVADEVR QLAERTSKST KEIADMIGRI
QTGTRSVIDD MQHSQEQARR GVELANEAGA AILGIRESTH KVVEAVQQFS RTLNADL
