ID   BDLF2_EBVA8             Reviewed;         420 AA.
AC   P0C742; Q777C4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   23-FEB-2022, entry version 21.
DE   RecName: Full=Protein BDLF2;
GN   ORFNames=BDLF2;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Rearranges cellular actin to increase intercellular contacts
CC       and thereby promote virus cell-to-cell spreading. Induce the outgrowth
CC       of long, branched plasma membrane fronds to create intercellular
CC       network for virion traffic. The fronds are actin based and RhoA-
CC       dependent (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with BMRF2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}.
CC   -!- DOMAIN: Plasma membrane remodeling is mediated by the cytoplasmic tail.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae BDLF2 family. {ECO:0000305}.
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DR   EMBL; DQ279927; ABB89271.1; -; Genomic_DNA.
DR   RefSeq; YP_001129491.1; NC_009334.1.
DR   RefSeq; YP_401695.1; NC_007605.1.
DR   DNASU; 3783693; -.
DR   GeneID; 3783693; -.
DR   GeneID; 5176177; -.
DR   KEGG; vg:3783693; -.
DR   KEGG; vg:5176177; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Glycoprotein; Late protein; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..420
FT                   /note="Protein BDLF2"
FT                   /id="PRO_0000408269"
FT   TOPO_DOM        1..184
FT                   /note="Intravirion"
FT   TRANSMEM        185..205
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..420
FT                   /note="Virion surface"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..81
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        264
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        304
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        371
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        384
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   420 AA;  46168 MW;  4CA5C00D0385E530 CRC64;
     MVDEQVAVEH GTVSHTISRE EDGVVHERRV LASGERVEVF YKAPAPRPRE GRASTFHDFT
     VPAAAAVPGP EPEPEPHPPM PIHANGGGET KTNTQDQNQN QTTRTRTNAK AEERTAEMDD
     TMASSGGQRG APISADLLSL SSLTGRMAAM APSWMKSEVC GERMRFKEDV YDGEAETLAE
     PPRCFMLSFV FIYYCCYLAF LALLAFGFNP LFLPSFMPVG AKVLRGKGRD FGVPLSYGCP
     TNPFCKVYTL IPAVVINNVT YYPNNTDSHG GHGGFEAAAL HVAALFESGC PNLQAVTNRN
     RTFNVTRASG RVERRLVQDM QRVLASAVVV MHHHCHYETY YVFDGVGPEF GTIPTPCFKD
     VLAFRPSLVT NCTAPLKTSV KGPNWSGAAG GMKRKQCRVD RLTDRSFPAY LEEVMYVMVQ