ABCG5_DICDI
ID ABCG5_DICDI Reviewed; 1509 AA.
AC Q54TV2; Q8T688;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=ABC transporter G family member 5;
DE AltName: Full=ABC transporter ABCG.5;
GN Name=abcG5; ORFNames=DDB_G0281391;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AF482384; AAL91490.1; -; Genomic_DNA.
DR EMBL; AAFI02000041; EAL66677.1; -; Genomic_DNA.
DR RefSeq; XP_640709.1; XM_635617.1.
DR AlphaFoldDB; Q54TV2; -.
DR SMR; Q54TV2; -.
DR STRING; 44689.DDB0215344; -.
DR PaxDb; Q54TV2; -.
DR PRIDE; Q54TV2; -.
DR EnsemblProtists; EAL66677; EAL66677; DDB_G0281391.
DR GeneID; 8623096; -.
DR KEGG; ddi:DDB_G0281391; -.
DR dictyBase; DDB_G0281391; abcG5.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_3_1; -.
DR InParanoid; Q54TV2; -.
DR OMA; NGARRCE; -.
DR PhylomeDB; Q54TV2; -.
DR PRO; PR:Q54TV2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IBA:GO_Central.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0031288; P:sorocarp morphogenesis; IBA:GO_Central.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 3.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1509
FT /note="ABC transporter G family member 5"
FT /id="PRO_0000330363"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 643..663
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 725..745
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1236..1256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1271..1291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1320..1340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1352..1372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1379..1399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1481..1501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 129..376
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 472..748
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 888..1141
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1231..1504
FT /note="ABC transmembrane type-2 2"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 168..175
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 935..942
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 137
FT /note="T -> P (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
FT CONFLICT 510
FT /note="F -> L (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
FT CONFLICT 1160
FT /note="E -> Q (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
FT CONFLICT 1172..1173
FT /note="EH -> VP (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
FT CONFLICT 1184
FT /note="N -> D (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
FT CONFLICT 1204
FT /note="V -> I (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
FT CONFLICT 1504
FT /note="V -> I (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
FT CONFLICT 1507
FT /note="L -> F (in Ref. 1; AAL91490)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1509 AA; 170937 MW; B6AA767896850909 CRC64;
MVKQDPRDKS SYSPNLSIPI NNQEEPTLNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNK
NNNNNNIKHK DEENDFEDSI YQIAKEHEGE EDDEYFPIPL DELMPNHEND ELTKKIKQTR
PEDKTGLYVY CRNATYTVKH RENKKVKIKL LDDVSFFLRP KQMTLILGTP GCGKSTIFQM
LAGQLKDKHF EGELLFNGHP INHKNHHRDI SYVTQDDIHV PTLTVKETFR FALDCLGKKE
LTREEKQVSV DNCMKLLGLK HAENTLVGDN FIRGISGGQK KRVTIGVGVI KGSNLLLMDE
PTSGLDSSTS FEILSDVKKF VTYGYSPALI TLLQPSVQLT SLFDNLMIMS KGKICYFGPM
NRALGYFKKL GFACPSHNNP AEFFQEVVDA PERYSFIHPP KCKTSDDFVK AYRESDIYLE
LMEKMDANKD GIVDDNKPKV LVDSTAKELG MYPHGIGYQT KICLKRGFIM ISRNYYNFAT
RVFKGIFFGL LLGTLYWRIG HNQSGGMERF GLLFFIMTTI IFSSFAAVNS FFGERKVFYS
QKALHYYKTG AYFISSIICD IPAGLIEVAF FGPIVYWLAN LRPVFIRFVY FMILLFITDN
LSLSFAKMCA AISPTIEIAN VTASVILSIW LLFSGFTAPK NDIGGWWIWL YYISPYTWIF
QGLSINEFTY QAYGCKDSEL IPPRTPQNLL PYPEGFGGNQ VCQYTSGEQI MDAFGINNPD
YFKWIVYAIL GAYIVFFYSV CFFALKYLNF EDKKSKLAVK KLKKKKKVIV CKEDEEPNCK
VTTEALERVS DDNDDNADIS NYDDDTVIDM KSPLTSPNYN NNNNLSGSGN NIKRRKVKTP
STLSPMVNSP LTNLSPMVNT PSKNGNHSKQ KPISTSQKDI SSETGSYLQF KKLCYAVDVK
ADDPDNPKKK KSQRLQLLTD IDGYVKPGQM LALMGPSGAG KSTLLDVLAQ RKTGGHITGE
ILINGKPPSE FTNRIRAYVE QMDVLPPTQT VREAIAFSAR CRLPPEVTKE EREIFVDKIV
EVLSLSSIKD LKIGVLGNGL SVSQRKRVNI GVELASNPEI LFLDEPTSGL DSGDAFKVID
VVNKIAKVMN RTVICTVHQP SAAIFEFFDQ LLLLKKGGET IYFGPLGNQS SVILDYCDKL
GMHIKPHINP ADFVMTLADE GKMVEGPNGE QEHLDAKKAY FESNICKKEY EIMEGQLIPD
DFVVKTYDSR FASSWMTQFR ALCMRSWLSR LRRPAIFVSN CLRSILLAVL LGTLFVRMDY
EQKDARSRVS LLFFSFLFAG MVAIGNIPTT VLERGVFYRE VTAGFYHSTA YMISYVLTSY
PFILSTGILY IIPTFWIAGL DSGRHSSKFW YCLFIFIITY IMYDAFALCL AVCLPNEVMA
STICGIGLSL ATLFGGFVIA RPNYPSAYYW CHYLDWLRYP LEASCTNEFT GLTFVCTNNK
GAVPIPIIEN GVQIAIKYYC PITNGDDFML TYGFHKFMRY IDIAAIFGYI FIFVGLSFWG
FKKVRWLNR
