BDNF_CHICK
ID BDNF_CHICK Reviewed; 246 AA.
AC P25429; Q45N27;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Brain-derived neurotrophic factor;
DE Short=BDNF;
DE Flags: Precursor;
GN Name=BDNF;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Leghorn; TISSUE=Liver;
RX PubMed=1457809; DOI=10.3109/10425179209039695;
RA Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.;
RT "Gene sequences of chicken BDNF and NT-3.";
RL DNA Seq. 3:49-54(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16611805; DOI=10.1523/jneurosci.0371-06.2006;
RA Katz A., Meiri N.;
RT "Brain-derived neurotrophic factor is critically involved in thermal-
RT experience-dependent developmental plasticity.";
RL J. Neurosci. 26:3899-3907(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 127-240.
RX PubMed=1906813; DOI=10.1016/0014-5793(91)80812-h;
RA Isackson P.J., Towner M.D., Huntsman M.M.;
RT "Comparison of mammalian, chicken and Xenopus brain-derived neurotrophic
RT factor coding sequences.";
RL FEBS Lett. 285:260-264(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 184-226.
RX PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA Hallboeoek F., Ibanez C.F., Persson H.;
RT "Evolutionary studies of the nerve growth factor family reveal a novel
RT member abundantly expressed in Xenopus ovary.";
RL Neuron 6:845-858(1991).
CC -!- FUNCTION: Important signaling molecule that activates signaling
CC cascades downstream of NTRK2 (By similarity). During development,
CC promotes the survival and differentiation of selected neuronal
CC populations of the peripheral and central nervous systems. Participates
CC in axonal growth, pathfinding and in the modulation of dendritic growth
CC and morphology. Major regulator of synaptic transmission and plasticity
CC at adult synapses in many regions of the CNS. The versatility of BDNF
CC is emphasized by its contribution to a range of adaptive neuronal
CC responses including long-term potentiation (LTP), long-term depression
CC (LTD), certain forms of short-term synaptic plasticity, as well as
CC homeostatic regulation of intrinsic neuronal excitability (By
CC similarity). {ECO:0000250|UniProtKB:P21237,
CC ECO:0000250|UniProtKB:P23560}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P23560}.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; M83377; AAC42220.1; -; Genomic_DNA.
DR EMBL; DQ124361; AAZ31074.1; -; mRNA.
DR EMBL; X61476; CAA43704.1; -; mRNA.
DR PIR; I50606; I50606.
DR RefSeq; NP_001026787.1; NM_001031616.1.
DR RefSeq; XP_015141637.1; XM_015286151.1.
DR RefSeq; XP_015141638.1; XM_015286152.1.
DR RefSeq; XP_015141639.1; XM_015286153.1.
DR RefSeq; XP_015141640.1; XM_015286154.1.
DR AlphaFoldDB; P25429; -.
DR SMR; P25429; -.
DR STRING; 9031.ENSGALP00000019837; -.
DR PaxDb; P25429; -.
DR Ensembl; ENSGALT00000019864; ENSGALP00000019837; ENSGALG00000012163.
DR Ensembl; ENSGALT00000083974; ENSGALP00000063948; ENSGALG00000012163.
DR Ensembl; ENSGALT00000089246; ENSGALP00000063414; ENSGALG00000012163.
DR GeneID; 396186; -.
DR KEGG; gga:396186; -.
DR CTD; 627; -.
DR VEuPathDB; HostDB:geneid_396186; -.
DR eggNOG; ENOG502QRU8; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_0_0_1; -.
DR InParanoid; P25429; -.
DR OMA; YPGMRTH; -.
DR OrthoDB; 1156054at2759; -.
DR PhylomeDB; P25429; -.
DR TreeFam; TF106463; -.
DR Reactome; R-GGA-9026527; Activated NTRK2 signals through PLCG1.
DR Reactome; R-GGA-9028731; Activated NTRK2 signals through FRS2 and FRS3.
DR Reactome; R-GGA-9032759; NTRK2 activates RAC1.
DR PRO; PR:P25429; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000012163; Expressed in cerebellum and 6 other tissues.
DR ExpressionAtlas; P25429; baseline and differential.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:0048672; P:positive regulation of collateral sprouting; IBA:GO_Central.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IDA:AgBase.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..127
FT /id="PRO_0000019649"
FT CHAIN 128..246
FT /note="Brain-derived neurotrophic factor"
FT /id="PRO_0000019650"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 140..207
FT /evidence="ECO:0000250|UniProtKB:P23560"
FT DISULFID 185..236
FT /evidence="ECO:0000250|UniProtKB:P23560"
FT DISULFID 195..238
FT /evidence="ECO:0000250|UniProtKB:P23560"
SQ SEQUENCE 246 AA; 27715 MW; CE1D93E99FDD3BA0 CRC64;
MTILFLTMVI SYFSCMKAAP MKEASVRGHG SLAYPGLRTH GTLESLTGPN AGSRGLTSLA
DTFEHVIEEL LDEDQDIQPS EENKDADLYT SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN
MSMRVRRHSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF
YETKCNPKGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL
TIKRGR
