ID   BDNF_CYPCA              Reviewed;         270 AA.
AC   Q90322;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Brain-derived neurotrophic factor;
DE            Short=BDNF;
DE   Flags: Precursor;
GN   Name=bdnf;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RA   Liu T.S., Chang G.D., Huang F.L., Lo T.B.;
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; L27171; AAA49204.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q90322; -.
DR   SMR; Q90322; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..151
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019651"
FT   CHAIN           152..270
FT                   /note="Brain-derived neurotrophic factor"
FT                   /id="PRO_0000019652"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        164..231
FT                   /evidence="ECO:0000250"
FT   DISULFID        209..260
FT                   /evidence="ECO:0000250"
FT   DISULFID        219..262
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   270 AA;  29572 MW;  049DE1ECE4742EAA CRC64;
     MTILFVTMVI SYFSCMRAAP MREIPGVQGG HRAEGYLGAA AAAAAAITSG SRGHGTPQSG
     GGLPWLTDTF EQVIEELLEV EGEATQQLGP GADQGQGGGG PAAMADSKDV DMYASRVMIS
     NQVPLEPPLL FLLEEYKNYL DAANMSMRVR RHSDPARRGE LSVCDSISQW VTALDKKTAI
     DMSGQTVTVL EKVPVTNGQL KQYFYETKCN PLGYTKEGCR GIDKRHYNSQ CRTTQSYVRA
     LTMDSKRKIG WRFIRIDTSC VCTLTIKRGR