ID   BDNF_PTYMJ              Reviewed;         246 AA.
AC   Q8QG74;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Brain-derived neurotrophic factor;
DE            Short=BDNF;
DE   Flags: Precursor;
GN   Name=BDNF;
OS   Ptyas major (Chinese green snake) (Cyclophiops major).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Colubridae; Colubrinae; Ptyas.
OX   NCBI_TaxID=192173;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Cao M., Yang Y.H., Zhang Y.Z.;
RT   "Molecular cloning of brain derived neurotrophic factor gene from
RT   amphibians and reptiles and its application in the research of phylogeny
RT   and taxonomy.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; AF497715; AAM18716.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8QG74; -.
DR   SMR; Q8QG74; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..127
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000346672"
FT   CHAIN           128..246
FT                   /note="Brain-derived neurotrophic factor"
FT                   /id="PRO_5000063074"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        140..207
FT                   /evidence="ECO:0000250"
FT   DISULFID        185..236
FT                   /evidence="ECO:0000250"
FT   DISULFID        195..238
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   246 AA;  27773 MW;  BA01780349F37856 CRC64;
     MTILFLTMVI SYLSCMKATP MKEVSIRGQG SLAYPGLRTQ GNLETLSGPN DATRGLTSLA
     DTFEHVIEEL LDERQVIQPS KENKDADLYS SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN
     MSMRVRRHSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF
     YETKCSTKGY AKEGCRGIDK RYWNSQCRTT QSYVRALTTD NKKRVGWRFI RIDTSCVCTL
     TIKRGR