ID   BDNF_RAMSP              Reviewed;         223 AA.
AC   Q1X6Z5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Brain-derived neurotrophic factor;
DE            Short=BDNF;
DE   Flags: Precursor; Fragment;
GN   Name=BDNF;
OS   Ramphotyphlops sp. (strain YPM 13663) (Blind snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Typhlopoidea; Typhlopidae; Ramphotyphlops;
OC   unclassified Ramphotyphlops.
OX   NCBI_TaxID=380608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16624591; DOI=10.1016/j.ympev.2006.03.010;
RA   Noonan B.P., Chippindale P.T.;
RT   "Dispersal and vicariance: the complex evolutionary history of boid
RT   snakes.";
RL   Mol. Phylogenet. Evol. 40:347-358(2006).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; AY988043; AAY44250.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1X6Z5; -.
DR   SMR; Q1X6Z5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Secreted; Signal.
FT   SIGNAL          <1..5
FT                   /evidence="ECO:0000255"
FT   PROPEP          6..114
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000346695"
FT   CHAIN           115..>223
FT                   /note="Brain-derived neurotrophic factor"
FT                   /id="PRO_0000346696"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        127..194
FT                   /evidence="ECO:0000250"
FT   DISULFID        172..223
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         223
SQ   SEQUENCE   223 AA;  25107 MW;  ADD73F4CA6514CD2 CRC64;
     SCMKAAPMKE VSLRGQGNLA YPGLRTQANL ENLGGPNDAT RGLTSLADTF EQVIEELLDE
     QQAIQPSKEN KDADLYSSRV MLSSQVPLEP PLLFLLEEYK NYLDAANMSM RVRRHSDPAR
     RGELSVCEST SEWVTAAEKK TAVDMSGATV TVLEKVPVPK GQLKQYFYET KCSSKGYTKE
     GCRGIDKRYW NSQCRTTQSY VRALTMDNKK RVGWRFIRID TSC