ID   BDNF_XENLA              Reviewed;         114 AA.
AC   P25432;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Brain-derived neurotrophic factor;
DE            Short=BDNF;
DE   Flags: Fragment;
GN   Name=bdnf;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1906813; DOI=10.1016/0014-5793(91)80812-h;
RA   Isackson P.J., Towner M.D., Huntsman M.M.;
RT   "Comparison of mammalian, chicken and Xenopus brain-derived neurotrophic
RT   factor coding sequences.";
RL   FEBS Lett. 285:260-264(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 58-100.
RC   TISSUE=Liver;
RX   PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; X61477; CAA43705.1; -; mRNA.
DR   PIR; I51599; I51599.
DR   AlphaFoldDB; P25432; -.
DR   SMR; P25432; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Reference proteome; Secreted.
FT   CHAIN           <1..>114
FT                   /note="Brain-derived neurotrophic factor"
FT                   /id="PRO_0000159611"
FT   DISULFID        14..81
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..112
FT                   /evidence="ECO:0000250"
FT   CONFLICT        73
FT                   /note="E -> D (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        96
FT                   /note="K -> R (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         114
SQ   SEQUENCE   114 AA;  13031 MW;  409A0CFB5E8EA887 CRC64;
     RHSDPARRGE LSVCDSISEW VTAANKKTAV DMSGATVTVL EKVPVSKGQL KQYFYETKCN
     PMGYMKEGCR GIEKRYWNSQ CRTTQSYVRA FTMDSKKKVG WRFIRIDTSC VCTL