ABCG6_DICDI
ID ABCG6_DICDI Reviewed; 1534 AA.
AC Q54TV1; Q8T687;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=ABC transporter G family member 6;
DE AltName: Full=ABC transporter ABCG.6;
GN Name=abcG6; ORFNames=DDB_G0281389;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-1534, AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000041; EAL66676.1; -; Genomic_DNA.
DR EMBL; AF482385; AAL91491.1; -; Genomic_DNA.
DR RefSeq; XP_640710.1; XM_635618.1.
DR AlphaFoldDB; Q54TV1; -.
DR SMR; Q54TV1; -.
DR STRING; 44689.DDB0215376; -.
DR PaxDb; Q54TV1; -.
DR PRIDE; Q54TV1; -.
DR EnsemblProtists; EAL66676; EAL66676; DDB_G0281389.
DR GeneID; 8623097; -.
DR KEGG; ddi:DDB_G0281389; -.
DR dictyBase; DDB_G0281389; abcG6.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_3_1; -.
DR InParanoid; Q54TV1; -.
DR OMA; YAKLILC; -.
DR PhylomeDB; Q54TV1; -.
DR PRO; PR:Q54TV1; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 3.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1534
FT /note="ABC transporter G family member 6"
FT /id="PRO_0000330364"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 734..754
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1261..1281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1296..1316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1345..1365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1377..1397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1404..1424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1506..1526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 138..385
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 481..757
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 924..1166
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1256..1529
FT /note="ABC transmembrane type-2 2"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 177..184
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 960..967
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 18
FT /note="I -> L (in Ref. 2; AAL91491)"
FT /evidence="ECO:0000305"
FT CONFLICT 51..52
FT /note="NN -> II (in Ref. 2; AAL91491)"
FT /evidence="ECO:0000305"
FT CONFLICT 824
FT /note="T -> P (in Ref. 2; AAL91491)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1534 AA; 173651 MW; AB3DE3CA581517DE CRC64;
MAKQDPKDKN SDSPNLSIPI NNNNNENLDN DQELLNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNLISSSR KHKDEESNYD SDDEKSVYQI AKEHEGEDDG DDEYFPIPLD ELMPNHENDE
LTKKIKQTRP EDKTGLYVYC RNATYTVKHR ENKKVKIKLI DDISFYLKPK EMTLILGTPG
CGKSTIFQML AGQLKDKHFK GELLFNGHPI NHKNHHRDIS YVTQDDIHVP TLTVKETFRF
ALDCLGRKEL TNEEKKETVD NCMNLLGLKE SENTVVGDNF VRGISGGQKK RVTIGVGVIK
GSNLLLMDEP TSGLDSSTSF EILSDVKKFV TYGYSPALIT LLQPSVQLTS LFDNLMILNK
GRICYFGPMN KALGYFKKLG FACPSHNNPA EFFQEVVDAP ERYSFIHPPK CKTSKDFVRA
YRESEFYKDL MEKMDANKDG IVDDNKPKVL VDSTAKELGM YPHGIGYQTK ICMKRGFTMI
RRNYYNFLTR VAKGIFFGLL LGTLYWRIGH NQSGGMERFG LLFFIMVTII FSSFAAVNSF
FGERKVFYSQ KALYYYKTGA YFISSIICDI PAGILEVAFF GPIVYWLANL RPVFIRFVYF
MLLLIMTDNL SLSFAKMCAA ISPTIEIANV IASVILSIWL LFSGFTAPKN DIGGWWIWLY
YISPYTWIFQ GLSINEFTYQ EYGCKTSELI PPRTPQNLLP YPEGFGGNQV CQFTSGEQIM
DAFGITNPNY FKWVVFGILS AYIVFFYVVC FFALKYFNFE DKKSKLAVKK LKKKKKVKTT
KQDEESAAIS SEALERIDDD NDDDADYETE IKKKKSHKKQ KEDTVIDVKS PSSLTTGSPY
YNINNNNNNL SGSGNNIKKR KVKTPSNLSP SVNSPITINS PMPTSPSNNN NNNNSNEKSK
NGKDIGSETG SYLQFKKLCY AVDVKVDDPD NPKKKKSQRL QLLTDIDGYV KPGQMLALMG
PSGAGKSTLL DVLAQRKTGG HITGEILING KPPSEFTNRI RAYVEQMDVL PPTQTVREAI
AFSARCRLPP EVTKEERESY VDKIVEVLSL SSIKDLKIGV LGDGLSVSQR KRVNIGVELA
SNPEILFLDE PTSGLDSGDA FKVIDVVNKI AKVMNRTVIC TVHQPSAAIF EFFDQLLLLK
QGGETIYFGP LGNQSSVILD YCDKLGMHIK PHINPADFVM TLADQGKMVE GPNGEQVPLD
AKKAYFESDI CKKEYEIMEG QLIPDDFVIK TYDSRFASSW MTQFRALCMR SWLSRLRRPA
IFVSNCIRSI LLAVLLGTLF VRMDYEQKDA RSRVSLLFFS FLFAGMVAIG NIPTTVLERG
VFYREVTAGF YHSTAYMTSY VLTSYPFTLS TGILYIIPTF WIAGLDSGRH SSKFWYCLFI
FIITYVMYDA FGLCLAVCLP NEVMASTICG IGLSLSTLFG GFVIARPNYP SAYYWCHYLD
WLRYPLEASC TNEFTGLTFV CTNNKGAVPI PIIENGVQIA IKYYCPITNG DDFMLTYGFH
KFMRYIDIAA IFGYIFIFVG LSFWGFKKIR WFNR
