ID   BDNF_XIPMA              Reviewed;         269 AA.
AC   Q02193;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Brain-derived neurotrophic factor;
DE            Short=BDNF;
DE   Flags: Precursor;
GN   Name=bdnf;
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1629719; DOI=10.1111/j.1471-4159.1992.tb09389.x;
RA   Gotz R., Raulf F., Schartl M.;
RT   "Brain-derived neurotrophic factor is more highly conserved in structure
RT   and function than nerve growth factor during vertebrate evolution.";
RL   J. Neurochem. 59:432-442(1992).
CC   -!- FUNCTION: BDNF promotes the survival of neuronal populations that are
CC       all located either in the central nervous system or directly connected
CC       to it.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; X59942; CAA42567.1; -; Genomic_DNA.
DR   PIR; I51708; I51708.
DR   AlphaFoldDB; Q02193; -.
DR   SMR; Q02193; -.
DR   STRING; 8083.ENSXMAP00000020028; -.
DR   eggNOG; ENOG502QRU8; Eukaryota.
DR   InParanoid; Q02193; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..150
FT                   /id="PRO_0000019653"
FT   CHAIN           151..269
FT                   /note="Brain-derived neurotrophic factor"
FT                   /id="PRO_0000019654"
FT   REGION          39..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          82..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        163..230
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..259
FT                   /evidence="ECO:0000250"
FT   DISULFID        218..261
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   269 AA;  29709 MW;  DAE774B79F2E5E52 CRC64;
     MTILFLTMVI SYFSCMRAAP LRDAPGMRGH WTEGYLGAAA TAPRGHGTPQ SGGGPGQREE
     LPSLTDTFEQ VIEELLEVEG EAAHVGQGAD KSQGGGGPSP VATAEANDVD LYNSRVMISN
     QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPSRRGEL SVCDSISQWV TAVDKKTAID
     MSGQTVTVME KVPVPNGQLK QYFYETKCNP MGYTKDGCRG IDKRHYTSQC RTTQSYVRAL
     TMDSKKKIGW RFIRIDTSCV CTLTIKRGR