ABCG7_DICDI
ID ABCG7_DICDI Reviewed; 815 AA.
AC Q8T686; Q54H76;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=ABC transporter G family member 7;
DE AltName: Full=ABC transporter ABCG.7;
GN Name=abcG7; ORFNames=DDB_G0289655;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC {ECO:0000305}.
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DR EMBL; AF482386; AAL91492.1; -; Genomic_DNA.
DR EMBL; AAFI02000148; EAL62539.1; -; Genomic_DNA.
DR RefSeq; XP_636042.1; XM_630950.1.
DR AlphaFoldDB; Q8T686; -.
DR SMR; Q8T686; -.
DR STRING; 44689.DDB0191231; -.
DR PaxDb; Q8T686; -.
DR EnsemblProtists; EAL62539; EAL62539; DDB_G0289655.
DR GeneID; 8627252; -.
DR KEGG; ddi:DDB_G0289655; -.
DR dictyBase; DDB_G0289655; abcG7.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q8T686; -.
DR OMA; ERYIYLR; -.
DR PhylomeDB; Q8T686; -.
DR Reactome; R-DDI-189451; Heme biosynthesis.
DR Reactome; R-DDI-189483; Heme degradation.
DR Reactome; R-DDI-917937; Iron uptake and transport.
DR Reactome; R-DDI-9753281; Paracetamol ADME.
DR PRO; PR:Q8T686; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IGC:dictyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..815
FT /note="ABC transporter G family member 7"
FT /id="PRO_0000391394"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 598..618
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 647..667
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 675..695
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 706..726
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 732..752
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 788..808
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 242..485
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 562..810
FT /note="ABC transmembrane type-2"
FT REGION 81..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 164..199
FT /evidence="ECO:0000255"
FT COMPBIAS 177..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 274..281
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 815 AA; 92419 MW; 5665336EFED31C95 CRC64;
MEVISINNTN CNNINNNIDN TNIDTNSIHN KNNIDNNIDN NNIDNNSIGN NNNNIDNNNN
NIANNNINNI NNIDNNIDNN NNIDNNNNKN NSNNYNNIDN NNNNNNNNNN NNNNNNNIDN
YNLVNNNNNN NNNSEISTPN FPYNNNNLTN LNSDNNIGVQ VIFENISYKT ENRNYKKQIK
DEKKRKKKLE MERSNSSNSN SSYDVESSAS GLQTPQQSRS SILPTNSLNI SKIDQSMNPQ
QTRSTTNGKI EKEITILSNV SGIIEKSEMV GLFGPSGSGK STLLDILANR KSTGTISGKI
LVNGKEIGDA YKKYCSYVTQ DEILLQTSTV EETLKFHADL RLPGLSDQDK WKVVEQVIKD
IGLTKKSKSK IGGILPGGMI VKGLSGGEKK RVSIGCALVT NPSLLFLDEP TSGLDSLNAL
KVMKVLMNLT VIKGVTVICS IHQPRPEIYH LFNKIMIMLK GRMIYCGNDV LNYLSSLPNQ
YQCPNYTNPA DFILDTCHEI SECDHYEEIC ESWETNWRDN MLAVSRIQPF NRSIEPNKSC
SLLYQYKILL NRNFKDFFRN STQYITRLSG GFMIGLLFSA CFGTLSPSQE DVLKISGILF
FLIAVLNLIP FTCITLFLSN REVFNSERAS KIYHSLPFYL STITTEAFIQ FLVSLIVSLL
VYTINHLRWN FSSFFITYFI LYLINLLSDL YIIAISNITG KSDLTFIYGT TISITFLLFM
GHLVPVKQLP KSFGWIHWLN PLYYGYATVM VAQFKDYPLE CPNDFCQFPN GNDVLKFYNL
EDWTLQKGIG IIILWICFFF VSGYWAISKL NKEKR
