ID   BDS2A_BUNCI             Reviewed;          41 AA.
AC   P84919;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=U-actitoxin-Bcs2a {ECO:0000303|PubMed:22683676};
DE            Short=U-AITX-Bcs2a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Neurotoxin BcIV {ECO:0000303|PubMed:17015047};
OS   Bunodosoma caissarum (Sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Bunodosoma.
OX   NCBI_TaxID=31165;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Nematoblast;
RX   PubMed=17015047; DOI=10.1016/j.bbapap.2006.08.010;
RA   Oliveira J.S., Zaharenko A.J., Ferreira W.A. Jr., Konno K., Shida C.S.,
RA   Richardson M., Lucio A.D., Beirao P.S.L., de Freitas J.C.;
RT   "BcIV, a new paralyzing peptide obtained from the venom of the sea anemone
RT   Bunodosoma caissarum. A comparison with the Na(+) channel toxin BcIII.";
RL   Biochim. Biophys. Acta 1764:1592-1600(2006).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Neurotoxin. Causes paralysis in crabs.
CC       {ECO:0000269|PubMed:17015047}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17015047}.
CC       Nematocyst {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=4670; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17015047};
CC   -!- MASS SPECTROMETRY: Mass=4670; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17015047};
CC   -!- SIMILARITY: Belongs to the sea anemone type 3 (BDS) potassium channel
CC       toxin family. {ECO:0000305}.
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DR   AlphaFoldDB; P84919; -.
DR   SMR; P84919; -.
DR   TCDB; 8.B.11.1.4; the sea anemone peptide toxin (apetx) family.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0030547; F:signaling receptor inhibitor activity; NAS:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR012414; BDS_K_chnl_tox.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   Pfam; PF07936; Defensin_4; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Nematocyst; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..41
FT                   /note="U-actitoxin-Bcs2a"
FT                   /evidence="ECO:0000269|PubMed:17015047"
FT                   /id="PRO_0000262965"
FT   DISULFID        4..38
FT                   /evidence="ECO:0000250|UniProtKB:P11494"
FT   DISULFID        6..31
FT                   /evidence="ECO:0000250|UniProtKB:P11494"
FT   DISULFID        21..39
FT                   /evidence="ECO:0000250|UniProtKB:P11494"
SQ   SEQUENCE   41 AA;  4675 MW;  D14CCEABFC4A29FB CRC64;
     GLPCDCHGHT GTYWLNYYSK CPKGYGYTGR CRYLVGSCCY K