ABCG8_DICDI
ID ABCG8_DICDI Reviewed; 626 AA.
AC Q86HQ2; Q555D5; Q8T684;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=ABC transporter G family member 8;
DE AltName: Full=ABC transporter ABCG.8;
GN Name=abcG8; ORFNames=DDB_G0274117;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; AF482387; AAL91493.1; -; Genomic_DNA.
DR EMBL; AAFI02000012; EAL69951.1; -; Genomic_DNA.
DR RefSeq; XP_644138.1; XM_639046.1.
DR AlphaFoldDB; Q86HQ2; -.
DR SMR; Q86HQ2; -.
DR STRING; 44689.DDB0191232; -.
DR PaxDb; Q86HQ2; -.
DR EnsemblProtists; EAL69951; EAL69951; DDB_G0274117.
DR GeneID; 8619568; -.
DR KEGG; ddi:DDB_G0274117; -.
DR dictyBase; DDB_G0274117; abcG8.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q86HQ2; -.
DR OMA; DLIPNRM; -.
DR PhylomeDB; Q86HQ2; -.
DR Reactome; R-DDI-189451; Heme biosynthesis.
DR Reactome; R-DDI-189483; Heme degradation.
DR Reactome; R-DDI-917937; Iron uptake and transport.
DR Reactome; R-DDI-9753281; Paracetamol ADME.
DR PRO; PR:Q86HQ2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..626
FT /note="ABC transporter G family member 8"
FT /id="PRO_0000391395"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 56..300
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 373..621
FT /note="ABC transmembrane type-2"
FT BINDING 90..97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 5
FT /note="T -> P (in Ref. 1; AAL91493)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="H -> P (in Ref. 1; AAL91493)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 626 AA; 70566 MW; 10F0BE9A71BD1EF2 CRC64;
MELETIEYNK SFNICENGDS KGVQLTFKNI SYKVENKNYN KNKKEKNKNK IDPEFVNLDN
KTENSNEKEI TILYNVGGVI EKGELVALMG PSGSGKSTLL DILAQRKSTG KITGQLLVNG
KEIGEAYKKY CSYVTQEDVL LQTYTVFETL KFYADLKLPG VSEIEKIKRV EKVIEDVGLT
LKRDSRVGGV LAGGVAVTGL SGGEKRRVSI GCGLITNPSL IFLDEPTSGL DSVAALQIMK
TLLNLTLKGV TVICSIHQPR PEIFQLINKV MVIIKGKMIY SGSNILEYFE SLGYPCPNNT
NPADFCLDSA VEIGEGERYT EICNQWENKW ENQLTNEIEY PSLNVDIPKT TSWVYQYWIL
LNREWRGFIR NKGNALSRVI TAIVIGALFG SCFAGLKESD ADVQKIMGTL FFLTTGLMLS
PFSMITLFLS GRQLFNSERA SKIYHSFPYF LSMITVELTI EFFVTLVEVT VCYMLARLRM
DAGRFFFAVL VYSFIHSLST FFISSLANLT GTSDLTFSYA SSLSVVFMLF AGFYVPTNEL
PRAFGWLHWV NPAFYGYSSV VINQFEDLQL KCTDEPCKFT NGNQVIEYYG IEDWTRGGSF
GVLVAWATFF YSLSYFALHF LHREKR
