BDS5A_HETCR
ID BDS5A_HETCR Reviewed; 41 AA.
AC P0DL87;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 1.
DT 25-MAY-2022, entry version 9.
DE RecName: Full=Pi-stichotoxin-Hcr5a {ECO:0000305};
DE Short=Pi-SHTX-Hcr5a {ECO:0000305};
DE AltName: Full=APETx-like peptide {ECO:0000250|UniProtKB:C0HL52};
DE AltName: Full=Pi-AnmTX Hcr 1b-1 {ECO:0000303|PubMed:23547468};
OS Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Stichodactylidae; Heteractis.
OX NCBI_TaxID=175771;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND SUBUNIT.
RX PubMed=23547468; DOI=10.1134/s1068162012060064;
RA Kozlov S.A., Osmakov D.I., Andreev I.A., Koshelev S.G., Gladkikh I.N.,
RA Monastyrnaia M.M., Kozlovskaia E.P., Grishin E.V.;
RT "Polypeptide toxin from sea anemone inhibiting proton-sensitive channel
RT ASIC3.";
RL Bioorg. Khim. 38:653-659(2012).
CC -!- FUNCTION: Weakly inhibits human homomeric ASIC3 (IC(50)=5.5 uM).
CC {ECO:0000269|PubMed:23547468}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23547468}.
CC Nematocyst {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=4537; Method=MALDI; Note=Average mass.;
CC Evidence={ECO:0000269|PubMed:23547468};
CC -!- SIMILARITY: Belongs to the sea anemone type 3 (BDS) potassium channel
CC toxin family. {ECO:0000305}.
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DR AlphaFoldDB; P0DL87; -.
DR SMR; P0DL87; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 2.20.20.10; -; 1.
DR InterPro; IPR012414; BDS_K_chnl_tox.
DR InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR Pfam; PF07936; Defensin_4; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Nematocyst; Proton-gated sodium channel impairing toxin; Secreted; Toxin.
FT PEPTIDE 1..41
FT /note="Pi-stichotoxin-Hcr5a"
FT /evidence="ECO:0000269|PubMed:23547468"
FT /id="PRO_0000443398"
FT DISULFID 4..37
FT /evidence="ECO:0000250|UniProtKB:P61541"
FT DISULFID 6..30
FT /evidence="ECO:0000250|UniProtKB:P61541"
FT DISULFID 20..38
FT /evidence="ECO:0000250|UniProtKB:P61541"
SQ SEQUENCE 41 AA; 4543 MW; 84600A73A8679829 CRC64;
GTPCKCHGYI GVYWFMLAGC PNGYGYNLSC PYFLGICCVD R
