ID   BDSF_ANEVI              Reviewed;          76 AA.
AC   P0DQN7;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Kappa-actitoxin-Avd4o {ECO:0000305};
DE            Short=Kappa-AITX-Avd4o {ECO:0000305};
DE   AltName: Full=Blood depressing substance 15 {ECO:0000303|PubMed:24177670};
DE            Short=BDS-15 {ECO:0000303|PubMed:24177670};
DE   Flags: Precursor;
OS   Anemonia viridis (Snakelocks anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anemonia.
OX   NCBI_TaxID=51769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING, AND TISSUE SPECIFICITY.
RX   PubMed=24177670; DOI=10.3390/md11114213;
RA   Nicosia A., Maggio T., Mazzola S., Cuttitta A.;
RT   "Evidence of accelerated evolution and ectodermal-specific expression of
RT   presumptive BDS toxin cDNAs from Anemonia viridis.";
RL   Mar. Drugs 11:4213-4231(2013).
CC   -!- FUNCTION: Blocks Kv3 voltage-gated potassium channels (By similarity).
CC       Reduces blood pressure (By similarity). {ECO:0000250|UniProtKB:P11494}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Experimental results show no expression in the
CC       ectodermal tissue from the distal and proximal tentacles, body wall,
CC       and oral disk. Since paralogs are expressed in this tissue, an
CC       expression of this toxin in this tissue is probable. The negative
CC       results could be explained by the very low abundance of EST sequences.
CC       {ECO:0000305|PubMed:24177670}.
CC   -!- SIMILARITY: Belongs to the sea anemone type 3 (BDS) potassium channel
CC       toxin family. {ECO:0000305}.
CC   -!- CAUTION: Opinions are divided on whether Anemonia viridis (Forsskal,
CC       1775) and Anemonia sulcata (Pennant, 1777) are separate species.
CC       {ECO:0000305}.
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DR   EMBL; FK725211; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0DQN7; -.
DR   SMR; P0DQN7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR012414; BDS_K_chnl_tox.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   Pfam; PF07936; Defensin_4; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hypotensive agent; Ion channel impairing toxin; Nematocyst;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..33
FT                   /evidence="ECO:0000250|UniProtKB:P0DMX9"
FT                   /id="PRO_0000451606"
FT   CHAIN           34..76
FT                   /note="Kappa-actitoxin-Avd4o"
FT                   /id="PRO_0000451607"
FT   DISULFID        37..72
FT                   /evidence="ECO:0000250|UniProtKB:P0DMX9"
FT   DISULFID        39..65
FT                   /evidence="ECO:0000250|UniProtKB:P0DMX9"
FT   DISULFID        55..73
FT                   /evidence="ECO:0000250|UniProtKB:P0DMX9"
SQ   SEQUENCE   76 AA;  8318 MW;  426C06663165315A CRC64;
     MNKALFLSLV VLCAAVVFAA EDLQKAKHAP FKLAAPCFCS GKPGRGDLWI FRGTCPGGYG
     YTSNCYKWPN ICCYPH