ID   BDSG_ANEVI              Reviewed;          43 AA.
AC   P0DQN6;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Kappa-actitoxin-Avd4p {ECO:0000305};
DE            Short=Kappa-AITX-Avd4p {ECO:0000305};
DE   AltName: Full=Blood depressing substance 16 {ECO:0000303|PubMed:29671760};
DE            Short=BDS-16 {ECO:0000303|PubMed:29671760};
OS   Anemonia viridis (Snakelocks anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anemonia.
OX   NCBI_TaxID=51769;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX   PubMed=29671760; DOI=10.3390/md16040134;
RA   Loret E.P., Luis J., Nuccio C., Villard C., Mansuelle P., Lebrun R.,
RA   Villard P.H.;
RT   "A low molecular weight protein from the sea anemone anemonia viridis with
RT   an anti-angiogenic activity.";
RL   Mar. Drugs 16:0-0(2018).
CC   -!- FUNCTION: Blocks Kv3 voltage-gated potassium channels (By similarity).
CC       Reduces blood pressure (By similarity). {ECO:0000250|UniProtKB:P11494}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=4692; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:29671760};
CC   -!- SIMILARITY: Belongs to the sea anemone type 3 (BDS) potassium channel
CC       toxin family. {ECO:0000305}.
CC   -!- CAUTION: Opinions are divided on whether Anemonia viridis (Forsskal,
CC       1775) and Anemonia sulcata (Pennant, 1777) are separate species.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DQN6; -.
DR   SMR; P0DQN6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR012414; BDS_K_chnl_tox.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   Pfam; PF07936; Defensin_4; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hypotensive agent;
KW   Ion channel impairing toxin; Nematocyst; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   CHAIN           1..43
FT                   /note="Kappa-actitoxin-Avd4p"
FT                   /evidence="ECO:0000269|PubMed:29671760"
FT                   /id="PRO_0000451608"
FT   DISULFID        4..39
FT                   /evidence="ECO:0000250|UniProtKB:P0DMX9"
FT   DISULFID        6..32
FT                   /evidence="ECO:0000250|UniProtKB:P0DMX9"
FT   DISULFID        22..40
FT                   /evidence="ECO:0000250|UniProtKB:P0DMX9"
SQ   SEQUENCE   43 AA;  4698 MW;  DC0C24C48A1FC3BE CRC64;
     AAPCSCPGKP GRGDLWIFRG TCPGGYGYTS NCYKWPNICC YPH