ID   BDSV_BUNCI              Reviewed;          33 AA.
AC   P86470;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Toxin BcV {ECO:0000303|Ref.1};
DE   Flags: Fragment;
OS   Bunodosoma caissarum (Sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Bunodosoma.
OX   NCBI_TaxID=31165;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RA   Zaharenko A.J., Ferreira W.A. Jr., Oliveira J.S., Madio B., Orts D.J.B.,
RA   Konno K., Richardson M., Freitas J.C.;
RL   Submitted (FEB-2010) to UniProtKB.
CC   -!- FUNCTION: Potently and reversibly blocks mammalian Kv11/KCNH/ERG
CC       voltage-gated potassium channels. Acts as a gating-modifier toxin that
CC       shifts the voltage-dependence of ERG activation in the positive
CC       direction and suppresses its current amplitudes elicited by strong
CC       depolarizing pulses that maximally activate the channels.
CC       {ECO:0000250|UniProtKB:P61541}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|Ref.1}. Nematocyst
CC       {ECO:0000305|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=4368; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the sea anemone type 3 (BDS) potassium channel
CC       toxin family. {ECO:0000255}.
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DR   AlphaFoldDB; P86470; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR012414; BDS_K_chnl_tox.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   Pfam; PF07936; Defensin_4; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Nematocyst; Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   CHAIN           1..>33
FT                   /note="Toxin BcV"
FT                   /id="PRO_0000392960"
FT   DISULFID        4..?
FT                   /evidence="ECO:0000250|UniProtKB:P61541"
FT   DISULFID        6..30
FT                   /evidence="ECO:0000250|UniProtKB:P61541"
FT   DISULFID        20..?
FT                   /evidence="ECO:0000250|UniProtKB:P61541"
FT   NON_TER         33
SQ   SEQUENCE   33 AA;  3536 MW;  10A58BF98771B910 CRC64;
     GTTCKCGSTL GIYWFAVTSC PPGRGYTTHC GYF