BEAN1_MOUSE
ID BEAN1_MOUSE Reviewed; 255 AA.
AC Q9EQG5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein BEAN1;
DE AltName: Full=Brain-expressed protein associating with Nedd4;
DE Short=BEAN;
GN Name=Bean1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH NEDD4, AND
RP MUTAGENESIS OF TYR-144 AND TYR-165.
RC TISSUE=Embryo;
RX PubMed=11042109; DOI=10.1042/bj3510557;
RA Jolliffe C.N., Harvey K.F., Haines B.P., Parasivam G., Kumar S.;
RT "Identification of multiple proteins expressed in murine embryos as binding
RT partners for the WW domains of the ubiquitin-protein ligase Nedd4.";
RL Biochem. J. 351:557-565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBUNIT: Interacts with NEDD4. {ECO:0000269|PubMed:11042109}.
CC -!- INTERACTION:
CC Q9EQG5; P46935: Nedd4; NbExp=3; IntAct=EBI-6304006, EBI-773516;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9EQG5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9EQG5-2; Sequence=VSP_031912;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG44395.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AK134633; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF240460; AAG44395.1; ALT_INIT; mRNA.
DR EMBL; AK134633; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS52646.1; -. [Q9EQG5-1]
DR RefSeq; NP_001135396.1; NM_001141924.1. [Q9EQG5-1]
DR RefSeq; XP_006531333.1; XM_006531270.1. [Q9EQG5-2]
DR AlphaFoldDB; Q9EQG5; -.
DR SMR; Q9EQG5; -.
DR BioGRID; 211138; 1.
DR IntAct; Q9EQG5; 1.
DR PhosphoSitePlus; Q9EQG5; -.
DR SwissPalm; Q9EQG5; -.
DR PRIDE; Q9EQG5; -.
DR Antibodypedia; 65669; 88 antibodies from 16 providers.
DR Ensembl; ENSMUST00000093245; ENSMUSP00000090931; ENSMUSG00000031872. [Q9EQG5-1]
DR Ensembl; ENSMUST00000167633; ENSMUSP00000131530; ENSMUSG00000031872. [Q9EQG5-1]
DR Ensembl; ENSMUST00000213077; ENSMUSP00000148283; ENSMUSG00000031872. [Q9EQG5-2]
DR GeneID; 65115; -.
DR KEGG; mmu:65115; -.
DR UCSC; uc009mzy.2; mouse. [Q9EQG5-1]
DR CTD; 146227; -.
DR MGI; MGI:1929597; Bean1.
DR VEuPathDB; HostDB:ENSMUSG00000031872; -.
DR GeneTree; ENSGT00390000003283; -.
DR HOGENOM; CLU_074372_0_0_1; -.
DR InParanoid; Q9EQG5; -.
DR BioGRID-ORCS; 65115; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Bean1; mouse.
DR PRO; PR:Q9EQG5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9EQG5; protein.
DR Bgee; ENSMUSG00000031872; Expressed in lumbar dorsal root ganglion and 57 other tissues.
DR ExpressionAtlas; Q9EQG5; baseline and differential.
DR Genevisible; Q9EQG5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039352; BEAN1.
DR PANTHER; PTHR36464; PTHR36464; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..255
FT /note="Protein BEAN1"
FT /id="PRO_0000322541"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 69..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..94
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..105
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11042109"
FT /id="VSP_031912"
FT MUTAGEN 144
FT /note="Y->A: Impairs binding to NEDD4."
FT /evidence="ECO:0000269|PubMed:11042109"
FT MUTAGEN 165
FT /note="Y->A: Impairs binding to NEDD4."
FT /evidence="ECO:0000269|PubMed:11042109"
SQ SEQUENCE 255 AA; 28538 MW; 20D3955C31A22B2F CRC64;
MSFKRPCPLA RYNRTSYFYP TTFSESSEHS HLLVSPVLVA SAVIGVVITL SCITIIVGSI
RRDRQARIQR HHHRHRRHHH HHRHRRRRHR EYASGGHTHS RSSPRMPYAC SPAEDWPPPL
DVSSEGDVDV TVLWELYPDS PPGYEECMGP GATQLYVPTD APPPYSMTDS CPRLNGALDS
DSGQSRSHRQ QEQRTQGQSR LHTVSMDTLP PYEAVCGTGS PSDLLPLPGP EPWPSNSQGS
PIPTQAPMPS PERIV
