ID   RUXE_CHICK              Reviewed;          92 AA.
AC   P62303; P08578; Q15498;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Small nuclear ribonucleoprotein E;
DE            Short=snRNP-E;
DE   AltName: Full=Sm protein E;
DE            Short=Sm-E;
DE            Short=SmE;
GN   Name=SNRPE;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=1478669; DOI=10.1016/s0888-7543(05)80109-0;
RA   Fautsch M., Thompson M.A., Holicky E.L., Schultz P.J., Hallett J.B.,
RA   Wieben E.D.;
RT   "Conservation of coding and transcriptional control sequences within the
RT   snRNP E protein gene.";
RL   Genomics 14:883-890(1992).
CC   -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC       spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC       (snRNPs), the building blocks of the spliceosome. Component of both the
CC       pre-catalytic spliceosome B complex and activated spliceosome C
CC       complexes. Is also a component of the minor U12 spliceosome. As part of
CC       the U7 snRNP it is involved in histone 3'-end processing.
CC       {ECO:0000250|UniProtKB:P62304}.
CC   -!- SUBUNIT: Core component of the spliceosomal U1, U2, U4 and U5 small
CC       nuclear ribonucleoproteins (snRNPs), the building blocks of the
CC       spliceosome. {ECO:0000250|UniProtKB:P62304}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P62304}. Nucleus {ECO:0000250|UniProtKB:P62304}.
CC       Note=SMN-mediated assembly into core snRNPs occurs in the cytosol
CC       before SMN-mediated transport to the nucleus to be included in
CC       spliceosomes. {ECO:0000250|UniProtKB:P62304}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR   EMBL; X65702; CAA46624.1; -; mRNA.
DR   EMBL; L19064; AAA49073.1; -; mRNA.
DR   RefSeq; NP_990581.1; NM_205250.1.
DR   AlphaFoldDB; P62303; -.
DR   SMR; P62303; -.
DR   MINT; P62303; -.
DR   STRING; 9031.ENSGALP00000000189; -.
DR   PaxDb; P62303; -.
DR   Ensembl; ENSGALT00000000190; ENSGALP00000000189; ENSGALG00000000137.
DR   GeneID; 396180; -.
DR   KEGG; gga:396180; -.
DR   CTD; 6635; -.
DR   VEuPathDB; HostDB:geneid_396180; -.
DR   eggNOG; KOG1774; Eukaryota.
DR   GeneTree; ENSGT00390000012818; -.
DR   HOGENOM; CLU_125186_1_0_1; -.
DR   InParanoid; P62303; -.
DR   OMA; TIWLYEQ; -.
DR   OrthoDB; 1594132at2759; -.
DR   PhylomeDB; P62303; -.
DR   TreeFam; TF314419; -.
DR   Reactome; R-GGA-111367; SLBP independent Processing of Histone Pre-mRNAs.
DR   Reactome; R-GGA-191859; snRNP Assembly.
DR   Reactome; R-GGA-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-GGA-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-GGA-73856; RNA Polymerase II Transcription Termination.
DR   Reactome; R-GGA-77588; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
DR   PRO; PR:P62303; -.
DR   Proteomes; UP000000539; Chromosome 26.
DR   Bgee; ENSGALG00000000137; Expressed in ovary and 14 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0034709; C:methylosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0034715; C:pICln-Sm protein complex; ISS:UniProtKB.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0034719; C:SMN-Sm protein complex; ISS:UniProtKB.
DR   GO; GO:0005685; C:U1 snRNP; ISS:UniProtKB.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0005687; C:U4 snRNP; ISS:UniProtKB.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; ISS:UniProtKB.
DR   CDD; cd01718; Sm_E; 1.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR027078; snRNP-E.
DR   PANTHER; PTHR11193; PTHR11193; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..92
FT                   /note="Small nuclear ribonucleoprotein E"
FT                   /id="PRO_0000125531"
SQ   SEQUENCE   92 AA;  10804 MW;  7D8881CE1F4FA2FD CRC64;
     MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD
     AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN