RUXE_DANRE
ID RUXE_DANRE Reviewed; 92 AA.
AC Q7ZUG0;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Small nuclear ribonucleoprotein E;
DE Short=snRNP-E;
DE AltName: Full=Sm protein E;
DE Short=Sm-E;
DE Short=SmE;
GN Name=snrpe; ORFNames=zgc:56682;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome. Component of both the
CC pre-catalytic spliceosome B complex and activated spliceosome C
CC complexes. Is also a component of the minor U12 spliceosome. As part of
CC the U7 snRNP it is involved in histone 3'-end processing.
CC {ECO:0000250|UniProtKB:P62304}.
CC -!- SUBUNIT: Core component of the spliceosomal U1, U2, U4 and U5 small
CC nuclear ribonucleoproteins (snRNPs), the building blocks of the
CC spliceosome. Most spliceosomal snRNPs contain a common set of Sm
CC proteins, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that
CC assemble in a heptameric protein ring on the Sm site of the small
CC nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1
CC snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb,
CC snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg, and at least three U1
CC snRNP-specific proteins snrnp70/u1-70k, snrpa/u1-a and snrpc/u1-c.
CC Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and
CC U5 snRNAs and at least prpf3, prpf4, prpf6, prpf8, prpf31, snrnp200,
CC txnl4a, snrnp40, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf, snrpg,
CC ddx23, cd2bp2, ppih, snu13, eftud2, sart1 and usp39, plus lsm2, lsm3,
CC lsm4, lsm5, lsm6, lsm7 and lsm8. Component of the U7 snRNP complex, or
CC U7 Sm protein core complex, that is composed of the U7 snRNA and at
CC least lsm10, lsm11, snrpb, snrpd3, snrpe, snrpf and snrpg; the complex
CC does not contain snrpd1 and snrpd2. Component of the U11/U12 snRNPs
CC that are part of the U12-type spliceosome. Part of the SMN-Sm complex
CC that contains smn1, gemin2/sip1, ddx20/gemin3, gemin4, gemin5, gemin6,
CC gemin7, gemin8, strap/unrip and the Sm proteins snrpb, snrpd1, snrpd2,
CC snrpd3, snrpe, snrpf and snrpg; catalyzes core snRNPs assembly. Forms a
CC 6S pICln-Sm complex composed of clns1a/pICln, snrpd1, snrpd2, snrpe,
CC snrpf and snrpg; ring-like structure where clns1a/pICln mimics
CC additional Sm proteins and which is unable to assemble into the core
CC snRNP. {ECO:0000250|UniProtKB:P62304}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P62304}. Nucleus {ECO:0000250|UniProtKB:P62304}.
CC Note=SMN-mediated assembly into core snRNPs occurs in the cytosol
CC before SMN-mediated transport to the nucleus to be included in
CC spliceosomes. {ECO:0000250|UniProtKB:P62304}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; BC049062; AAH49062.1; -; mRNA.
DR RefSeq; NP_957298.1; NM_201004.1.
DR AlphaFoldDB; Q7ZUG0; -.
DR SMR; Q7ZUG0; -.
DR STRING; 7955.ENSDARP00000050295; -.
DR PaxDb; Q7ZUG0; -.
DR PRIDE; Q7ZUG0; -.
DR Ensembl; ENSDART00000050296; ENSDARP00000050295; ENSDARG00000033175.
DR GeneID; 393979; -.
DR KEGG; dre:393979; -.
DR CTD; 6635; -.
DR ZFIN; ZDB-GENE-040426-1112; snrpe.
DR eggNOG; KOG1774; Eukaryota.
DR GeneTree; ENSGT00390000012818; -.
DR HOGENOM; CLU_125186_1_0_1; -.
DR InParanoid; Q7ZUG0; -.
DR OMA; TIWLYEQ; -.
DR OrthoDB; 1594132at2759; -.
DR PhylomeDB; Q7ZUG0; -.
DR TreeFam; TF314419; -.
DR Reactome; R-DRE-191859; snRNP Assembly.
DR Reactome; R-DRE-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-DRE-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:Q7ZUG0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 11.
DR Bgee; ENSDARG00000033175; Expressed in tail bud paraxial mesoderm and 28 other tissues.
DR ExpressionAtlas; Q7ZUG0; baseline and differential.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0034709; C:methylosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0034715; C:pICln-Sm protein complex; ISS:UniProtKB.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0034719; C:SMN-Sm protein complex; ISS:UniProtKB.
DR GO; GO:0005685; C:U1 snRNP; ISS:UniProtKB.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR GO; GO:0005687; C:U4 snRNP; ISS:UniProtKB.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; ISS:UniProtKB.
DR CDD; cd01718; Sm_E; 1.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR027078; snRNP-E.
DR PANTHER; PTHR11193; PTHR11193; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..92
FT /note="Small nuclear ribonucleoprotein E"
FT /id="PRO_0000125532"
SQ SEQUENCE 92 AA; 10789 MW; 53E89E2E26CC5825 CRC64;
MAYRGQGQKV QKVMVQPINL IFRYLQNRSR ISVWLYEQVN MRIEGCIIGF DEYMNLVLDD
AEEVHMKTKN RKPLGRIMLK GDNITLLQSV SN
