ID   RUXE_SCHPO              Reviewed;          84 AA.
AC   Q9USZ3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Small nuclear ribonucleoprotein E {ECO:0000250|UniProtKB:Q12330};
DE            Short=snRNP-E {ECO:0000250|UniProtKB:Q12330};
DE   AltName: Full=Sm protein E;
DE            Short=Sm-E {ECO:0000250|UniProtKB:Q12330};
DE            Short=SmE {ECO:0000250|UniProtKB:Q12330};
GN   Name=sme1 {ECO:0000312|EMBL:CAB59808.1}; ORFNames=SPBC11G11.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAB59808.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3] {ECO:0000305}
RP   IDENTIFICATION IN U1 SNRNP BY MASS SPECTROMETRY.
RX   PubMed=17264129; DOI=10.1093/nar/gkl1144;
RA   Newo A.N.S., Luetzelberger M., Bottner C.A., Wehland J., Wissing J.,
RA   Jaensch L., Kaeufer N.F.;
RT   "Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals
RT   three essential organism-specific proteins.";
RL   Nucleic Acids Res. 35:1391-1401(2007).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Binds and is required for the
CC       stability of snRNA U1, U2, U4 and U5 which contain a highly conserved
CC       structural motif called the Sm binding site. Involved in cap
CC       modification (By similarity). {ECO:0000250|UniProtKB:P62304}.
CC   -!- SUBUNIT: Component of the Sm core complex, present in spliceosomal
CC       snRNP U1, U2, U4/U6 and U5. The core complex contains smb1, smd1, smd2,
CC       smd3, sme1, smf1 and smg1 (Sm proteins B, D1, D2, D3, E, F and G,
CC       respectively), and is probably a heptameric ring structure.
CC       {ECO:0000250|UniProtKB:Q12330, ECO:0000269|PubMed:17264129}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000255}.
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DR   EMBL; CU329671; CAB59808.1; -; Genomic_DNA.
DR   PIR; T39333; T39333.
DR   RefSeq; NP_595724.1; NM_001021622.2.
DR   PDB; 3JB9; EM; 3.60 A; H/m=1-84.
DR   PDBsum; 3JB9; -.
DR   AlphaFoldDB; Q9USZ3; -.
DR   SMR; Q9USZ3; -.
DR   BioGRID; 276165; 18.
DR   IntAct; Q9USZ3; 2.
DR   STRING; 4896.SPBC11G11.06c.1; -.
DR   MaxQB; Q9USZ3; -.
DR   PaxDb; Q9USZ3; -.
DR   EnsemblFungi; SPBC11G11.06c.1; SPBC11G11.06c.1:pep; SPBC11G11.06c.
DR   GeneID; 2539607; -.
DR   KEGG; spo:SPBC11G11.06c; -.
DR   PomBase; SPBC11G11.06c; sme1.
DR   VEuPathDB; FungiDB:SPBC11G11.06c; -.
DR   eggNOG; KOG1774; Eukaryota.
DR   HOGENOM; CLU_125186_1_1_1; -.
DR   InParanoid; Q9USZ3; -.
DR   OMA; TIWLYEQ; -.
DR   PhylomeDB; Q9USZ3; -.
DR   Reactome; R-SPO-72165; mRNA Splicing - Minor Pathway.
DR   PRO; PR:Q9USZ3; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IDA:PomBase.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0005685; C:U1 snRNP; IDA:PomBase.
DR   GO; GO:0005686; C:U2 snRNP; IDA:PomBase.
DR   GO; GO:0071004; C:U2-type prespliceosome; ISO:PomBase.
DR   GO; GO:0005687; C:U4 snRNP; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISO:PomBase.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IC:PomBase.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR   CDD; cd01718; Sm_E; 1.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR027078; snRNP-E.
DR   PANTHER; PTHR11193; PTHR11193; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..84
FT                   /note="Small nuclear ribonucleoprotein E"
FT                   /id="PRO_0000349132"
SQ   SEQUENCE   84 AA;  9691 MW;  F74655EA6D48793D CRC64;
     MSGRVQKVMI PPINFIFKLL QQHTPVSIWL FEQTDIRLQG QIRGFDEFMN IVLDDAVQVD
     AKNNKRELGR ILLKGDNITL IQAI