RUXF_CAEEL
ID RUXF_CAEEL Reviewed; 85 AA.
AC P34659;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Probable small nuclear ribonucleoprotein F;
DE Short=snRNP-F;
DE AltName: Full=Sm protein F;
DE Short=Sm-F;
DE Short=SmF;
GN Name=snr-5; ORFNames=ZK652.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome (By similarity).
CC {ECO:0000250|UniProtKB:P62306}.
CC -!- INTERACTION:
CC P34659; Q18786: snr-4; NbExp=4; IntAct=EBI-328740, EBI-327286;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62306}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62306}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. SmF/LSm6
CC subfamily. {ECO:0000305}.
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DR EMBL; FO080278; CCD62546.1; -; Genomic_DNA.
DR PIR; S44901; S44901.
DR RefSeq; NP_498708.1; NM_066307.4.
DR AlphaFoldDB; P34659; -.
DR SMR; P34659; -.
DR BioGRID; 41311; 25.
DR DIP; DIP-27408N; -.
DR IntAct; P34659; 3.
DR STRING; 6239.ZK652.1; -.
DR EPD; P34659; -.
DR PaxDb; P34659; -.
DR PeptideAtlas; P34659; -.
DR PRIDE; P34659; -.
DR EnsemblMetazoa; ZK652.1.1; ZK652.1.1; WBGene00004918.
DR GeneID; 176103; -.
DR KEGG; cel:CELE_ZK652.1; -.
DR UCSC; ZK652.1.1; c. elegans.
DR CTD; 176103; -.
DR WormBase; ZK652.1; CE00446; WBGene00004918; snr-5.
DR eggNOG; KOG3482; Eukaryota.
DR GeneTree; ENSGT00940000154818; -.
DR HOGENOM; CLU_076902_12_1_1; -.
DR InParanoid; P34659; -.
DR OMA; VKLKWGH; -.
DR OrthoDB; 1600677at2759; -.
DR PhylomeDB; P34659; -.
DR Reactome; R-CEL-111367; SLBP independent Processing of Histone Pre-mRNAs.
DR Reactome; R-CEL-191859; snRNP Assembly.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR Reactome; R-CEL-77588; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
DR PRO; PR:P34659; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00004918; Expressed in embryo and 4 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:InterPro.
DR CDD; cd01722; Sm_F; 1.
DR InterPro; IPR016487; Lsm6/sSmF.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR034100; Sm_F.
DR PANTHER; PTHR11021; PTHR11021; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..85
FT /note="Probable small nuclear ribonucleoprotein F"
FT /id="PRO_0000125540"
SQ SEQUENCE 85 AA; 9250 MW; 695FB7562623345B CRC64;
MSAVQPVNPK PFLNSLTGKF VVCKLKWGME YKGVLVAVDS YMNLQLAHAE EYIDGNSQGN
LGEILIRCNN VLYVGGVDGE NETSA
