ID   RV161_CANAL             Reviewed;         264 AA.
AC   Q5AFE4; A0A1D8PQG7;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Regulator of cytoskeleton and endocytosis RVS161 {ECO:0000305};
GN   Name=RVS161; OrderedLocusNames=CAALFM_C700020CA;
GN   ORFNames=CaO19.7124, orf19.7124;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=19596778; DOI=10.1128/iai.00683-09;
RA   Douglas L.M., Martin S.W., Konopka J.B.;
RT   "BAR domain proteins Rvs161 and Rvs167 contribute to Candida albicans
RT   endocytosis, morphogenesis, and virulence.";
RL   Infect. Immun. 77:4150-4160(2009).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND INDUCTION.
RX   PubMed=19824012; DOI=10.1002/pmic.200800958;
RA   Yin Z., Stead D., Walker J., Selway L., Smith D.A., Brown A.J., Quinn J.;
RT   "A proteomic analysis of the salt, cadmium and peroxide stress responses in
RT   Candida albicans and the role of the Hog1 stress-activated MAPK in
RT   regulating the stress-induced proteome.";
RL   Proteomics 9:4686-4703(2009).
CC   -!- FUNCTION: Component of a cytoskeletal structure that is required for
CC       the formation of endocytic vesicles at the plasma membrane level. Plays
CC       an important role in virulence. {ECO:0000269|PubMed:19596778}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P25343}.
CC   -!- INDUCTION: Expression is induced in absence of HOG1 under non-stressed
CC       conditions. {ECO:0000269|PubMed:19824012}.
CC   -!- DISRUPTION PHENOTYPE: Leads to defects in actin polarization,
CC       endocytosis, bud morphogenesis, as well as increased sensitivity to
CC       calcofluor white and Congo red. Shows also a strong defect of hyphal
CC       morphogenesis and attenuated virulence. {ECO:0000269|PubMed:19596778}.
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DR   EMBL; CP017629; AOW30381.1; -; Genomic_DNA.
DR   RefSeq; XP_720414.2; XM_715321.2.
DR   AlphaFoldDB; Q5AFE4; -.
DR   SMR; Q5AFE4; -.
DR   BioGRID; 1221099; 3.
DR   STRING; 237561.Q5AFE4; -.
DR   PRIDE; Q5AFE4; -.
DR   GeneID; 3638005; -.
DR   KEGG; cal:CAALFM_C700020CA; -.
DR   CGD; CAL0000193274; RVS161.
DR   VEuPathDB; FungiDB:C7_00020C_A; -.
DR   HOGENOM; CLU_072096_0_0_1; -.
DR   InParanoid; Q5AFE4; -.
DR   OMA; TRFCAYF; -.
DR   OrthoDB; 1172471at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0030479; C:actin cortical patch; IBA:GO_Central.
DR   GO; GO:0043332; C:mating projection tip; IBA:GO_Central.
DR   GO; GO:0031097; C:medial cortex; IBA:GO_Central.
DR   GO; GO:1990528; C:Rvs161p-Rvs167p complex; IBA:GO_Central.
DR   GO; GO:0051666; P:actin cortical patch localization; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   Pfam; PF03114; BAR; 1.
DR   SMART; SM00721; BAR; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   PROSITE; PS51021; BAR; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Endocytosis; Reference proteome; Virulence.
FT   CHAIN           1..264
FT                   /note="Regulator of cytoskeleton and endocytosis RVS161"
FT                   /id="PRO_0000430556"
FT   DOMAIN          15..239
FT                   /note="BAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
SQ   SEQUENCE   264 AA;  30084 MW;  EBB46B4D000E6BB4 CRC64;
     MSWGGFKKAI NRAGASVIVK DVDKTMDKDF DVEERRYKTL KTAGTNLQKA AKGYLDNIRA
     ITNSQVTIAE IIYNLYEESK QGQSLYSNVG TYYMQSVKEF DEETVKQIDG PYRETVLDPI
     GKFSNYFSEI DEAIKKRAHK KIDYEQCKAK VRRLVDKPAK DAAKLPRAEK ELSMAKEIYD
     ELNDQLKAEL PQLIALRVPF YDPSFEALVK IQLRFCTEGY SRLAQIQQYL DPASRDEYAN
     GLLDGKIDDM LAQMQGLSIT SLGK