ID   BECN1_PICGU             Reviewed;         461 AA.
AC   A5DIV5; Q4A1C0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Autophagy-related protein 6;
DE   AltName: Full=Beclin-1-like protein;
GN   Name=ATG6; ORFNames=PGUG_03206;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Botti J., Djavaheri-Mergny M., Codogno P., Oriol R.;
RT   "Phylogeny and biochemistry of the autophagy protein beclin 1.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and
CC       autophagy. Also involved in endosome-to-Golgi retrograde transport (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beclin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ26341.1; Type=Erroneous translation; Note=Wrong genetic code used for translating the sequence.; Evidence={ECO:0000305};
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DR   EMBL; AM072826; CAJ26341.1; ALT_SEQ; mRNA.
DR   EMBL; CH408157; EDK39108.2; -; Genomic_DNA.
DR   RefSeq; XP_001485477.1; XM_001485427.1.
DR   AlphaFoldDB; A5DIV5; -.
DR   SMR; A5DIV5; -.
DR   STRING; 4929.XP_001485477.1; -.
DR   EnsemblFungi; EDK39108; EDK39108; PGUG_03206.
DR   GeneID; 5127116; -.
DR   KEGG; pgu:PGUG_03206; -.
DR   VEuPathDB; FungiDB:PGUG_03206; -.
DR   eggNOG; KOG2751; Eukaryota.
DR   HOGENOM; CLU_024219_3_2_1; -.
DR   InParanoid; A5DIV5; -.
DR   OMA; DTFCIGH; -.
DR   OrthoDB; 1085752at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0006914; P:autophagy; IEA:InterPro.
DR   Gene3D; 1.10.418.40; -; 1.
DR   InterPro; IPR007243; Atg6/Beclin.
DR   InterPro; IPR038274; Atg6/Beclin_C_sf.
DR   InterPro; IPR041691; Atg6/beclin_CC.
DR   InterPro; IPR040455; Atg6_BARA.
DR   PANTHER; PTHR12768; PTHR12768; 1.
DR   Pfam; PF04111; APG6; 1.
DR   Pfam; PF17675; APG6_N; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..461
FT                   /note="Autophagy-related protein 6"
FT                   /id="PRO_0000295036"
FT   REGION          75..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          194..286
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  52303 MW;  7F7C36FDD0894C6E CRC64;
     MFYCSKCNAP LQIDHSLQDA NTGQLNLLTQ NKQSVSAAAP KLNSVDFIPK ERLELLEEVE
     KNGHNEPIHF LDTIEEHGTD SSPDHDSSPD ASLVVNGGEI EEPVPVSAPS PESSEADGPN
     PISGRIHTLE KIFDILSNKG EVNHPMCDEC AELLIENYKL KFDQNQREKD SYMTFLKKLK
     LKDDSDIKES DLDTKLRDSI QECRDLAASE QEKLQELRSL EQNREELSKE LQDVKMELAL
     QQSTELSNAL RLKNELHWTL QRKADQLAQE KARYRVVLNR LDHLRNLNMY TKFFDIAADD
     QFGKINGFRL GYKVPWSEVN CALGQVVLLA VFLCKRLDVR LQSYKLVPMG SRSQIVKLSS
     DHDKSKTVLN LYSSNELSLG KLFNFNKLDV SMIALLDVLS QIEATVLALD SEIELPYTIS
     PKKDVIGGKS IRVTSNSDWT FSCKFLLVNF KWILTYASSR H