RV161_YEAST
ID RV161_YEAST Reviewed; 265 AA.
AC P25343; D6VR18;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Reduced viability upon starvation protein 161;
GN Name=RVS161; Synonyms=END6, SPE161; OrderedLocusNames=YCR009C;
GN ORFNames=YCR9C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 44827 / SKQ2N;
RX PubMed=2183524; DOI=10.1002/yea.320060212;
RA Urdaci M., Dulau L., Aigle M., Crouzet M.;
RT "Sequence of the yeast gene RVS 161 located on chromosome III.";
RL Yeast 6:173-176(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1626432; DOI=10.1002/yea.320080508;
RA Skala J., Purnelle B., Goffeau A.;
RT "The complete sequence of a 10.8 kb segment distal of SUF2 on the right arm
RT of chromosome III from Saccharomyces cerevisiae reveals seven open reading
RT frames including the RVS161, ADP1 and PGK genes.";
RL Yeast 8:409-417(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP CHARACTERIZATION.
RC STRAIN=ATCC 44827 / SKQ2N;
RX PubMed=1776363; DOI=10.1002/yea.320070708;
RA Crouzet M., Urdaci M., Dulau L., Aigle M.;
RT "Yeast mutant affected for viability upon nutrient starvation:
RT characterization and cloning of the RVS161 gene.";
RL Yeast 7:727-743(1991).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Component of a cytoskeletal structure that is required for
CC the formation of endocytic vesicles at the plasma membrane level.
CC -!- INTERACTION:
CC P25343; P39743: RVS167; NbExp=16; IntAct=EBI-14490, EBI-14500;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- MISCELLANEOUS: Mutations in this gene results in sensitivity to carbon,
CC nitrogen and sulfur starvation.
CC -!- MISCELLANEOUS: Present with 7390 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X63315; CAA44926.1; -; Genomic_DNA.
DR EMBL; X59720; CAA42326.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07487.1; -; Genomic_DNA.
DR PIR; S19516; S19516.
DR RefSeq; NP_009935.1; NM_001178722.1.
DR AlphaFoldDB; P25343; -.
DR SMR; P25343; -.
DR BioGRID; 30988; 1035.
DR ComplexPortal; CPX-1335; RVS161-RVS167 amphiphysin complex.
DR DIP; DIP-1601N; -.
DR IntAct; P25343; 49.
DR MINT; P25343; -.
DR STRING; 4932.YCR009C; -.
DR TCDB; 8.A.34.2.1; the endophilin (endophilin) family.
DR iPTMnet; P25343; -.
DR MaxQB; P25343; -.
DR PaxDb; P25343; -.
DR PRIDE; P25343; -.
DR EnsemblFungi; YCR009C_mRNA; YCR009C; YCR009C.
DR GeneID; 850367; -.
DR KEGG; sce:YCR009C; -.
DR SGD; S000000602; RVS161.
DR VEuPathDB; FungiDB:YCR009C; -.
DR eggNOG; KOG3771; Eukaryota.
DR GeneTree; ENSGT00950000182882; -.
DR HOGENOM; CLU_072096_0_0_1; -.
DR InParanoid; P25343; -.
DR OMA; TRFCAYF; -.
DR BioCyc; YEAST:G3O-29326-MON; -.
DR PRO; PR:P25343; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P25343; protein.
DR GO; GO:0030479; C:actin cortical patch; IDA:SGD.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0005937; C:mating projection; IDA:SGD.
DR GO; GO:0043332; C:mating projection tip; HDA:SGD.
DR GO; GO:0031097; C:medial cortex; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IDA:SGD.
DR GO; GO:1990528; C:Rvs161p-Rvs167p complex; IPI:SGD.
DR GO; GO:0008092; F:cytoskeletal protein binding; IPI:SGD.
DR GO; GO:0051666; P:actin cortical patch localization; IMP:SGD.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:SGD.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; IMP:SGD.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0000747; P:conjugation with cellular fusion; IMP:SGD.
DR GO; GO:0006897; P:endocytosis; IMP:SGD.
DR GO; GO:0060988; P:lipid tube assembly; IDA:SGD.
DR GO; GO:0097320; P:plasma membrane tubulation; IDA:SGD.
DR GO; GO:0030100; P:regulation of endocytosis; IDA:ComplexPortal.
DR GO; GO:0006970; P:response to osmotic stress; IMP:SGD.
DR GO; GO:0042594; P:response to starvation; IMP:SGD.
DR CDD; cd07591; BAR_Rvs161p; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR037429; Rvs161/Hob3_BAR.
DR Pfam; PF03114; BAR; 1.
DR SMART; SM00721; BAR; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR PROSITE; PS51021; BAR; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..265
FT /note="Reduced viability upon starvation protein 161"
FT /id="PRO_0000192960"
FT DOMAIN 15..239
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT COILED 126..193
FT /evidence="ECO:0000255"
FT CONFLICT 95
FT /note="Q -> E (in Ref. 1; CAA44926)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 265 AA; 30250 MW; B35EA00E0C900E2D CRC64;
MSWEGFKKAI NRAGHSVIIK NVDKTIDKEY DMEERRYKVL QRAGEALQKE AKGFLDSLRA
VTASQTTIAE VISNLYDDSK YVAGGGYNVG NYYLQCVQDF DSETVKQLDG PLRETVLDPI
TKFSTYFKEI EEAIKKRDHK KQDFDAAKAK VRRLVDKPAK DASKLPRAEK ELSLAKDIFE
NLNNQLKTEL PQLVSLRVPY FDPSFEALIK IQLRFCTDGY TRLAQIQQYL DQQSRDDYAN
GLLDTKIEEL LGQMTSLDIC ALGIK
