RVE2_ARATH
ID RVE2_ARATH Reviewed; 287 AA.
AC F4K5X6; Q6NML6; Q6R0G3;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Protein REVEILLE 2;
DE AltName: Full=MYB family transcription factor Circadian 1;
GN Name=RVE2; Synonyms=CIR1; OrderedLocusNames=At5g37260; ORFNames=MNJ8.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-287.
RA Kim C.J., Chen H., Cheuk R., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17587236; DOI=10.1111/j.1365-313x.2007.03156.x;
RA Zhang X., Chen Y., Wang Z.Y., Chen Z., Gu H., Qu L.J.;
RT "Constitutive expression of CIR1 (RVE2) affects several circadian-regulated
RT processes and seed germination in Arabidopsis.";
RL Plant J. 51:512-525(2007).
RN [6]
RP INDUCTION, DISRUPTION PHENOTYPE, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19805390; DOI=10.1073/pnas.0813035106;
RA Rawat R., Schwartz J., Jones M.A., Sairanen I., Cheng Y., Andersson C.R.,
RA Zhao Y., Ljung K., Harmer S.L.;
RT "REVEILLE1, a Myb-like transcription factor, integrates the circadian clock
RT and auxin pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:16883-16888(2009).
RN [7]
RP ALTERNATIVE SPLICING, AND REGULATION.
RX PubMed=22747664; DOI=10.1186/1745-6150-7-20;
RA Filichkin S.A., Mockler T.C.;
RT "Unproductive alternative splicing and nonsense mRNAs: a widespread
RT phenomenon among plant circadian clock genes.";
RL Biol. Direct 7:20-20(2012).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, AND REGULATION.
RX PubMed=23371945; DOI=10.1105/tpc.112.108340;
RA Guan Q., Wu J., Zhang Y., Jiang C., Liu R., Chai C., Zhu J.;
RT "A DEAD box RNA helicase is critical for pre-mRNA splicing, cold-responsive
RT gene regulation, and cold tolerance in Arabidopsis.";
RL Plant Cell 25:342-356(2013).
CC -!- FUNCTION: Positive regulator for cold-responsive gene expression and
CC cold tolerance. Part of a regulatory feedback loop that controls a
CC subset of the circadian outputs and modulates the central oscillator.
CC Negatively self-regulates its own expression.
CC {ECO:0000269|PubMed:17587236, ECO:0000269|PubMed:23371945}.
CC -!- INTERACTION:
CC F4K5X6; A1YKT1: TCP18; NbExp=3; IntAct=EBI-15194007, EBI-15192731;
CC F4K5X6; Q9LXG0: ZHD8; NbExp=3; IntAct=EBI-15194007, EBI-1806405;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- INDUCTION: Circadian-regulation. Peak of transcript abundance near
CC subjective dawn. Up-regulated transiently by light.
CC {ECO:0000269|PubMed:17587236, ECO:0000269|PubMed:19805390}.
CC -!- DISRUPTION PHENOTYPE: No effect on the regulation of core clock
CC associated genes or on the hypocotyl length, but hypersensitivity to
CC freezing stress and slightly earlier-flowering phenotype. Rve1 and rve2
CC double mutant has no alteration in the period or phase of the clock.
CC Rve1, rve2 and rve7 triple mutant has no alteration in the period or
CC phase of the clock. {ECO:0000269|PubMed:17587236,
CC ECO:0000269|PubMed:19805390, ECO:0000269|PubMed:23371945}.
CC -!- MISCELLANEOUS: Regulated at the level of mRNA maturation by RH42
CC (PubMed:23371945). The RVE2 pre-mRNA can be alternatively spliced,
CC generating a poison cassette exon that harbors an very early in-frame
CC premature termination codon. The resulting severely truncated mRNA is
CC not efficiently translated (PubMed:22747664).
CC {ECO:0000305|PubMed:22747664, ECO:0000305|PubMed:23371945}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAR24725.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAS47647.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY519515; AAS09985.1; -; mRNA.
DR EMBL; AB017069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED94158.1; -; Genomic_DNA.
DR EMBL; BT010947; AAR24725.1; ALT_INIT; mRNA.
DR EMBL; BT011641; AAS47647.1; ALT_INIT; mRNA.
DR RefSeq; NP_198542.1; NM_123085.3.
DR AlphaFoldDB; F4K5X6; -.
DR SMR; F4K5X6; -.
DR BioGRID; 18951; 123.
DR IntAct; F4K5X6; 99.
DR STRING; 3702.AT5G37260.1; -.
DR PaxDb; F4K5X6; -.
DR PRIDE; F4K5X6; -.
DR EnsemblPlants; AT5G37260.1; AT5G37260.1; AT5G37260.
DR GeneID; 833700; -.
DR Gramene; AT5G37260.1; AT5G37260.1; AT5G37260.
DR KEGG; ath:AT5G37260; -.
DR Araport; AT5G37260; -.
DR TAIR; locus:2169135; AT5G37260.
DR eggNOG; KOG0724; Eukaryota.
DR HOGENOM; CLU_030536_0_0_1; -.
DR InParanoid; F4K5X6; -.
DR OMA; AMQERCE; -.
DR OrthoDB; 1118093at2759; -.
DR PRO; PR:F4K5X6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4K5X6; baseline and differential.
DR Genevisible; F4K5X6; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0007623; P:circadian rhythm; IEP:TAIR.
DR GO; GO:0009909; P:regulation of flower development; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009845; P:seed germination; IMP:TAIR.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW Biological rhythms; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..287
FT /note="Protein REVEILLE 2"
FT /id="PRO_0000424836"
FT DOMAIN 31..85
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 58..81
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 134..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 230
FT /note="N -> D (in Ref. 1; AAS09985)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 32436 MW; E23BC0425A406BF0 CRC64;
MAMQERCESL CSDELISSSD AFYLKTRKPY TITKQREKWT EAEHEKFVEA LKLYGRAWRR
IEEHVGTKTA VQIRSHAQKF FTKVARDFGV SSESIEIPPP RPKRKPMHPY PRKLVIPDAK
EMVYAELTGS KLIQDEDNRS PTSVLSAHGS DGLGSIGSNS PNSSSAELSS HTEESLSLEA
ETKQSLKLFG KTFVVGDYNS SMSCDDSEDG KKKLYSETQS LQCSSSTSEN AETEVVVSEF
KRSERSAFSQ LKSSVTEMNN MRGFMPYKKR VKVEENIDNV KLSYPLW
