RVE4_ARATH
ID RVE4_ARATH Reviewed; 293 AA.
AC Q6R0G4; B9DG39; Q94B26;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein REVEILLE 4 {ECO:0000303|PubMed:19805390};
DE AltName: Full=Myb transcription factor LHY/CCA1-like 1 {ECO:0000303|Ref.2};
GN Name=RVE4 {ECO:0000303|PubMed:19805390}; Synonyms=LCL1 {ECO:0000303|Ref.2};
GN OrderedLocusNames=At5g02840 {ECO:0000312|Araport:AT5G02840};
GN ORFNames=F9G14.150 {ECO:0000312|EMBL:AL162973};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Schmied K.C., Merkle T.;
RT "A small family of LHY-CCA1-like (LCL) MYB1R transcription factors:
RT potential co-regulators of the circadian oscillator.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17363273; DOI=10.1016/j.jsb.2006.12.012;
RA Martini J., Schmied K., Palmisano R., Toensing K., Anselmetti D.,
RA Merkle T.;
RT "Multifocal two-photon laser scanning microscopy combined with photo-
RT activatable GFP for in vivo monitoring of intracellular protein dynamics in
RT real time.";
RL J. Struct. Biol. 158:401-409(2007).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19805390; DOI=10.1073/pnas.0813035106;
RA Rawat R., Schwartz J., Jones M.A., Sairanen I., Cheng Y., Andersson C.R.,
RA Zhao Y., Ljung K., Harmer S.L.;
RT "REVEILLE1, a Myb-like transcription factor, integrates the circadian clock
RT and auxin pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:16883-16888(2009).
RN [9]
RP INTERACTION WITH LNK1 AND LNK2.
RX PubMed=25012192; DOI=10.1105/tpc.114.126573;
RA Xie Q., Wang P., Liu X., Yuan L., Wang L., Zhang C., Li Y., Xing H.,
RA Zhi L., Yue Z., Zhao C., McClung C.R., Xu X.;
RT "LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis
RT circadian oscillator.";
RL Plant Cell 26:2843-2857(2014).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250,
CC ECO:0000269|PubMed:17363273}.
CC -!- SUBUNIT: Interacts with LNK1 and LNK2. {ECO:0000269|PubMed:25012192}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:17363273}. Cytoplasm {ECO:0000269|PubMed:17363273}.
CC Note=Actively translocating nucleo-cytoplasmic shuttle protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6R0G4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6R0G4-2; Sequence=VSP_053508;
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DR EMBL; AY519514; AAS09984.1; -; mRNA.
DR EMBL; AJ937209; CAI77450.1; -; mRNA.
DR EMBL; AL162973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED90524.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90525.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90526.1; -; Genomic_DNA.
DR EMBL; AY042894; AAK68834.1; -; mRNA.
DR EMBL; AY081522; AAM10084.1; -; mRNA.
DR EMBL; AK317012; BAH19706.1; -; mRNA.
DR RefSeq; NP_001031823.1; NM_001036746.2. [Q6R0G4-2]
DR RefSeq; NP_568108.1; NM_120362.4. [Q6R0G4-1]
DR RefSeq; NP_850756.1; NM_180425.2. [Q6R0G4-1]
DR AlphaFoldDB; Q6R0G4; -.
DR SMR; Q6R0G4; -.
DR BioGRID; 17042; 17.
DR IntAct; Q6R0G4; 11.
DR STRING; 3702.AT5G02840.1; -.
DR iPTMnet; Q6R0G4; -.
DR PaxDb; Q6R0G4; -.
DR PRIDE; Q6R0G4; -.
DR ProteomicsDB; 228033; -. [Q6R0G4-1]
DR EnsemblPlants; AT5G02840.1; AT5G02840.1; AT5G02840. [Q6R0G4-1]
DR EnsemblPlants; AT5G02840.2; AT5G02840.2; AT5G02840. [Q6R0G4-1]
DR EnsemblPlants; AT5G02840.3; AT5G02840.3; AT5G02840. [Q6R0G4-2]
DR GeneID; 831766; -.
DR Gramene; AT5G02840.1; AT5G02840.1; AT5G02840. [Q6R0G4-1]
DR Gramene; AT5G02840.2; AT5G02840.2; AT5G02840. [Q6R0G4-1]
DR Gramene; AT5G02840.3; AT5G02840.3; AT5G02840. [Q6R0G4-2]
DR KEGG; ath:AT5G02840; -.
DR Araport; AT5G02840; -.
DR TAIR; locus:2151251; AT5G02840.
DR eggNOG; KOG0724; Eukaryota.
DR InParanoid; Q6R0G4; -.
DR OMA; EERPMET; -.
DR PhylomeDB; Q6R0G4; -.
DR PRO; PR:Q6R0G4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6R0G4; baseline and differential.
DR Genevisible; Q6R0G4; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0007623; P:circadian rhythm; IMP:TAIR.
DR GO; GO:0042752; P:regulation of circadian rhythm; IGI:TAIR.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..293
FT /note="Protein REVEILLE 4"
FT /id="PRO_0000424837"
FT DOMAIN 43..97
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 70..93
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 188..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 278..293
FT /note="SEYVDAAEEGHEHLSS -> RKVMNT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19423640"
FT /id="VSP_053508"
FT CONFLICT 207
FT /note="S -> T (in Ref. 5; AAK68834/AAM10084)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 293 AA; 32207 MW; D65545ED99457C5F CRC64;
MTSTNPVVAE VIPAETSTDA TETTIATTEA GEAPEKKVRK AYTITKSRES WTEGEHDKFL
EALQLFDRDW KKIEDFVGSK TVIQIRSHAQ KYFLKVQKNG TLAHVPPPRP KRKAAHPYPQ
KASKNAQMSL HVSMSFPTQI NNLPGYTPWD DDTSALLNIA VSGVIPPEDE LDTLCGAEVD
VGSNDMISET SPSASGIGSS SRTLSDSKGL RLAKQAPSMH GLPDFAEVYN FIGSVFDPDS
KGRMKKLKEM DPINFETVLL LMRNLTVNLS NPDFEPTSEY VDAAEEGHEH LSS
