RVE8_ARATH
ID RVE8_ARATH Reviewed; 298 AA.
AC Q8RWU3; Q6QAC9; Q9SF43;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 148.
DE RecName: Full=Protein REVEILLE 8;
DE AltName: Full=MYB-like transcription factor;
DE AltName: Full=Protein LHY-CCA1-like 5;
GN Name=RVE8; Synonyms=LCL5; OrderedLocusNames=At3g09600; ORFNames=F11F8.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Schmied K.C., Merkle T.;
RT "A small family of LHY-CCA1-like (LCL) MYB1R transcription factors:
RT potential co-regulators of the circadian oscillator.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19805390; DOI=10.1073/pnas.0813035106;
RA Rawat R., Schwartz J., Jones M.A., Sairanen I., Cheng Y., Andersson C.R.,
RA Zhao Y., Ljung K., Harmer S.L.;
RT "REVEILLE1, a Myb-like transcription factor, integrates the circadian clock
RT and auxin pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:16883-16888(2009).
RN [7]
RP FUNCTION, AND INDUCTION.
RX PubMed=21205033; DOI=10.1111/j.1365-313x.2011.04484.x;
RA Farinas B., Mas P.;
RT "Functional implication of the MYB transcription factor RVE8/LCL5 in the
RT circadian control of histone acetylation.";
RL Plant J. 66:318-329(2011).
RN [8]
RP FUNCTION.
RX PubMed=21474993; DOI=10.4161/psb.6.4.14837;
RA Farinas B., Mas P.;
RT "Histone acetylation and the circadian clock: a role for the MYB
RT transcription factor RVE8/LCL5.";
RL Plant Signal. Behav. 6:541-543(2011).
RN [9]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21483796; DOI=10.1371/journal.pgen.1001350;
RA Rawat R., Takahashi N., Hsu P.Y., Jones M.A., Schwartz J., Salemi M.R.,
RA Phinney B.S., Harmer S.L.;
RT "REVEILLE8 and PSEUDO-RESPONSE REGULATOR5 form a negative feedback loop
RT within the Arabidopsis circadian clock.";
RL PLoS Genet. 7:E1001350-E1001350(2011).
RN [10]
RP ALTERNATIVE SPLICING, INDUCTION, AND REGULATION.
RX PubMed=22902701; DOI=10.4161/psb.21491;
RA James A.B., Syed N.H., Brown J.W., Nimmo H.G.;
RT "Thermoplasticity in the plant circadian clock: how plants tell the time-
RT perature.";
RL Plant Signal. Behav. 7:1219-1223(2012).
RN [11]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23638299; DOI=10.7554/elife.00473;
RA Hsu P.Y., Devisetty U.K., Harmer S.L.;
RT "Accurate timekeeping is controlled by a cycling activator in
RT Arabidopsis.";
RL Elife 2:E00473-E00473(2013).
CC -!- FUNCTION: Transcriptional activator of evening element (EE)-containing
CC clock-controlled genes. Forms a negative feedback loop with APRR5.
CC Regulates the pattern of histone H3 acetylation of the TOC1 promoter.
CC {ECO:0000269|PubMed:21205033, ECO:0000269|PubMed:21474993,
CC ECO:0000269|PubMed:21483796, ECO:0000269|PubMed:23638299}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8RWU3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8RWU3-2; Sequence=VSP_053512, VSP_053513;
CC -!- INDUCTION: Circadian-regulation. Peak of expression in the afternoon.
CC Down-regulated by cold. {ECO:0000269|PubMed:21205033,
CC ECO:0000269|PubMed:22902701, ECO:0000269|PubMed:23638299}.
CC -!- DISRUPTION PHENOTYPE: Delay and reduction in levels of evening-phased
CC clock gene transcripts and long circadian period.
CC {ECO:0000269|PubMed:21483796, ECO:0000269|PubMed:23638299}.
CC -!- MISCELLANEOUS: Subject to temperature associated alternative splicing
CC producing mainly non-productive mRNAs. {ECO:0000305|PubMed:22902701}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF23291.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC016661; AAF23291.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74786.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74787.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65370.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65371.1; -; Genomic_DNA.
DR EMBL; AY091106; AAM14056.1; -; mRNA.
DR EMBL; AY122969; AAM67502.1; -; mRNA.
DR EMBL; AY550307; AAS58518.1; -; mRNA.
DR EMBL; AJ937213; CAI77454.1; -; mRNA.
DR RefSeq; NP_001030662.1; NM_001035585.4. [Q8RWU3-2]
DR RefSeq; NP_001327348.1; NM_001337832.1. [Q8RWU3-1]
DR RefSeq; NP_001327349.1; NM_001337831.1. [Q8RWU3-2]
DR RefSeq; NP_187571.2; NM_111794.4. [Q8RWU3-1]
DR AlphaFoldDB; Q8RWU3; -.
DR SMR; Q8RWU3; -.
DR BioGRID; 5451; 6.
DR STRING; 3702.AT3G09600.1; -.
DR iPTMnet; Q8RWU3; -.
DR PaxDb; Q8RWU3; -.
DR ProteomicsDB; 232679; -. [Q8RWU3-1]
DR EnsemblPlants; AT3G09600.1; AT3G09600.1; AT3G09600. [Q8RWU3-1]
DR EnsemblPlants; AT3G09600.2; AT3G09600.2; AT3G09600. [Q8RWU3-2]
DR EnsemblPlants; AT3G09600.6; AT3G09600.6; AT3G09600. [Q8RWU3-2]
DR EnsemblPlants; AT3G09600.7; AT3G09600.7; AT3G09600. [Q8RWU3-1]
DR GeneID; 820117; -.
DR Gramene; AT3G09600.1; AT3G09600.1; AT3G09600. [Q8RWU3-1]
DR Gramene; AT3G09600.2; AT3G09600.2; AT3G09600. [Q8RWU3-2]
DR Gramene; AT3G09600.6; AT3G09600.6; AT3G09600. [Q8RWU3-2]
DR Gramene; AT3G09600.7; AT3G09600.7; AT3G09600. [Q8RWU3-1]
DR KEGG; ath:AT3G09600; -.
DR Araport; AT3G09600; -.
DR TAIR; locus:2075049; AT3G09600.
DR eggNOG; KOG0724; Eukaryota.
DR InParanoid; Q8RWU3; -.
DR OMA; FHNIGST; -.
DR OrthoDB; 1109519at2759; -.
DR PhylomeDB; Q8RWU3; -.
DR PRO; PR:Q8RWU3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8RWU3; baseline and differential.
DR Genevisible; Q8RWU3; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0032922; P:circadian regulation of gene expression; IMP:TAIR.
DR GO; GO:0043966; P:histone H3 acetylation; IMP:TAIR.
DR GO; GO:0048573; P:photoperiodism, flowering; IMP:TAIR.
DR GO; GO:0042753; P:positive regulation of circadian rhythm; IMP:TAIR.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:TAIR.
DR GO; GO:0042752; P:regulation of circadian rhythm; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Biological rhythms; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..298
FT /note="Protein REVEILLE 8"
FT /id="PRO_0000424842"
FT DOMAIN 38..92
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 65..88
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 269..282
FT /note="RKVLLSYDNVTTEL -> SDCNDAAEESPLII (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4, ECO:0000303|Ref.5"
FT /id="VSP_053512"
FT VAR_SEQ 283..298
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4, ECO:0000303|Ref.5"
FT /id="VSP_053513"
SQ SEQUENCE 298 AA; 32801 MW; AA5507ECC670EB78 CRC64;
MSSSPSRNPT NAEAPPPPPT STDAVAEGSS KKVRKPYTIT KSRESWTEEE HDKFLEALQL
FDRDWKKIED FVGSKTVIQI RSHAQKYFLK VQKNGTLAHV PPPRPKRKAA HPYPQKASKN
AQMPLQVSTS FTTTRNGDMP GYASWDDASM LLNRVISPQH ELATLRGAEA DIGSKGLLNV
SSPSTSGMGS SSRTVSGSEI VRKAKQPPVL HGVPDFAEVY NFIGSVFDPE TRGHVEKLKE
MDPINFETVL LLMRNLTVNL SNPDLESTRK VLLSYDNVTT ELPSVVSLVK NSTSDKSA
